Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series

Raphaela Silva Leandro Santos; Marilia Ferreira Andrade; Fabio de Abreu Alves; Luiz Paulo Kowalski; Danyel Elias da Cruz Perez

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저자정보: Raphaela Silva Leandro Santos Marilia Ferreira Andrade Fabio de Abreu Alves Luiz Paulo Kowalski Danyel Elias da Cruz Perez

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제1호

발행연도: 2016.1

수록면: 80 - 84 (5page)

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Objectives. Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. Methods. Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical reactions were performed in the cases submitted to biopsy. Results. All patients were males and the mean age was 40.5 years old. The sites of the metastatic tumors were gingival mucosa, floor of the mouth, oropharynx, and larynx. Two tumors appeared as submucosal nodules with normal color; one lesion was a blackish nodular lesion, and one was shown to be an ulcerated lesion. The size of tumors ranged from 2.0 to 4.0 cm. All patients had developed systemic disease at time of diagnosis of metastatic tumor in the head and neck mucosa. Survival rates ranged from 2 to 19 months after the diagnosis of the metastatic mucosal melanoma in the head and neck region. Conclusion. Although rare, patients with melanoma must be closely and regularly followed up, with careful routine examination of head and neck, because metastatic tumors in this region seem to be part of a lethal widespread metastatic disease.

#Keywords. Head and Neck Neoplasms #Melanoma #Mouth #Mucous Membrane #Neoplasm Metastasis

참고문헌 (21)

참고문헌 신청

Lengyel E. / 2003 / Malignant mucosal melanoma of the head and neck / Pathol Oncol Res 9(1):7~12

Patrick RJ. / 2007 / Primary mucosal melanoma / J Am Acad Dermatol 56(5):828~834

Henderson LT. / 1986 / Upper aerodigestive tract metastases in disseminated malignant melanoma / Arch Otolaryngol Head Neck Surg 112(6):659~663

Billings KR. / 1995 / Clinical and pathologic distinction between primary and metastatic mucosal melanoma of the head and neck / Otolaryngol Head Neck Surg 112(6):700~706

L. Barlas Aydogan / 1996 / Malignant Melanoma Metastatic to the Tonsil / The Laryngoscope 106(3):313~316

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