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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 181 - 187 (7page)
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Head and neck squamous cell carcinoma has emerged as the sixth most commonly occurring cancer worldwide and despite advances in diagnostics and therapeutics, the treatment results and survival outcomes still remain poor, especially in advanced cancers. Due to the complexity of the local anatomic structures and the importance as vital functioning organs, the head and neck area following conventional treatment modalities such as surgery, chemotherapy, or radiotherapy often result as a devastating consequence both esthetically and functionally. In order to minimize the treatment related sequelae and at the same time maximize treatment effect, tumor-specific molecular targeted therapy has become an area under active research. Several molecular targeted agents, including the representative epidermal growth factor receptor (EGFR)-inhibitors have been developed and its therapeutic effects investigated. However, therapeutic resistance has newly risen as a main problem following targeted therapy due to a variety of resistance mechanisms. This review article looks at the major acquired resistance mechanisms following targeted agents administration including EGFR inhibitors and many others and strategies to overcome the resistance to achieve precision medicine.
Korean J Otorhinolaryngol-Head Neck Surg 2016;59(3):181-7
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참고문헌 (42)
참고문헌 신청
Siegel R / 2013 / Cancer statistics, 2013 / CA Cancer J Clin 63(1):11~30
Yonesaka K / 2011 / Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab / Sci Transl Med 3(99):99
Harrington KJ / 2009 / Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck / J Clin Oncol 27(7):1100~1107
Erjala K / 2006 / Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells / Clin Cancer Res 12(13):4103~4111
Harari PM / 2009 / Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond / Semin Radiat Oncol 19(1):63~68
Yonesaka K / 2011 / Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab / Sci Transl Med 3(99):99
Harrington KJ / 2009 / Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck / J Clin Oncol 27(7):1100~1107
Erjala K / 2006 / Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells / Clin Cancer Res 12(13):4103~4111
Harari PM / 2009 / Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond / Semin Radiat Oncol 19(1):63~68
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