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Background and Objectives:This study was designed to compare the clinical outcomes according to surgical approach of extranasal, endonasal endoscopic, and a combined approach of the two, suggesting the indication of each surgical approach for excision of sinonasal inverted papiloma (IP). Subjects and Method:Fifty-six IP patients who had been operated at the de-assessed. The patients were arbitrarily divided into three groups such as excision through extranasal approach (EEA), endonasal endoscopic excision (EEE), and EE combined with Caldwell-Lucs aproach (EEE+ C-L) group. Results:The most com-monly afected sites by CT/MRI preoperatively was the nasal cavity folowed in the decreasing order of frequency by maxilary, ethmoid, sphenoid, and frontal sinus. In the EEA group, the originated sites were the nasal cavity (2/6), maxillary (1/6), and frontal sinus (2/6). In the EE group, the origin sites by operative findings were the nasal cavity (30/41), maxillary (5/41), sp-henoid (3/41), and ethmoid (2/41) sinus. In the E + C-L group, eight cases (8/9) originated from the maxillary sinus. There were six cases associated with malignant tumors, five synchronous and one metachronous, treated combined with radiotherapy (1/6) in EEA, 14.6% (6/41) in EE and 10.1% (1/9) in EEE+C-L group, and there was no significant diference acording to surgical approaches. Conclusion:E yielded a sucesful outcome only when the IP was limited to the originating sites of nasal cavity, medial and uper wall of maxillary sinus, ethmoid sinus, and sphenoid sinus. The complete removal of the tumor by EE alone could not be achieved when the tumor was originated from the anterior, inferior, and posterolateral wall of maxillary sinus, requiring aplication of C-Ls aproach at the same time. EA can be used with more benefits than EE when the tumor is originated from the frontal sinus or when the mas tends to invade extensively.

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