기니픽에서 Cisplatin 이독성에 대한 Procaine Hydrochloride의     예방적 효과

김아영; 김동현; 박재용; 한욱경; 최진웅; 박용호

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자료유형: 학술저널

저자정보: 김아영 김동현 박재용 한욱경 최진웅 박용호

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제10호

발행연도: 2007.1

수록면: 854 - 859 (6page)

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Background and Objectives: The use of cisplatin is limited by dose-dependent nephrotoxicity, ototoxicity. Some papers dem-onstrated that procaine hydrochloride increases the therapeutic index of cisplatin, reducing nephrotoxicity, improving antitumor city. Materials and Method：Procaine hydrochloride was used to prevent the ototoxic efects of cisplatin. To evaluate the eficacy, ABR threshold shifts and histopathologic examinations were performed. Results：After injection of cisplatin, ABR indicated that procaine hydrochloride reduced threshold shift significantly. The cochlear hair cels, especially outer hair cels in basal turn, were severely damaged in cisplatin treated group comparing to cisplatin/procaine hydrochloride treated group. In cisplatin/ pro-caine hydrochloride treated cochlea, the apoptotic cells were decreased compared to cisplatin treated group. Conclusion：Proca-ine hydrochloride might protect cisplatin induced ototoxicity in guinea pigs. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :854-9)

#Cisplatin·이독성·Procaine hydrochloride. #Cisplatin· Ototoxicity· Procaine hydrochloride.

참고문헌 (13)

참고문헌 신청

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/ / Litterst CL. Alterations in the toxicity of cis-dichlorodiaminep-latinum-I and in tisue localization of platinum as a function of NaCl concentration in the vehicle of adm

/ / Swinerton KD. Phase I study of high-dose cis-dichlorodiamineplatinum : 367 ~ 70

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