조기성문암에서 방사선치료 실패의 위험인자와 구제수술의 치료결과

이세우; 김무필; 박세진; 정광윤; 우정수; 권순영; 백승국; 김철용

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자료유형: 학술저널

저자정보: 이세우 김무필 박세진 정광윤 우정수 권순영 백승국 김철용

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제3호

발행연도: 2008.1

수록면: 261 - 265 (5page)

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The aim of this study was to find risk factors for recurrence after curative radiotherapy in early glottic cancer and to analyze the result of treatment between salvage total laryngectomy and salvage conservation laryngectomy for recurrent glottic cancer. Subjects and Method：A retrospective analysis was performed for patients of 45 cases of early glottic cancer who were treated with curative radiotherapy from 1997 to 2004. The risk factors analyzed for recurrence in early glottic cancer were gender, age, anterior involvement, bilaterality, T stage and radiotherapy interruption. Fourteen patients who underwent salvage laryngectomy for recurrent glottic cancer were analyzed by Kaplan-Myer method to assess the results of salvage total laryngectomy and salvage conservation laryngectomy. Results：Forty-two patients were male and only 3 patients were female, with the median age of 62.4 years. Radiotherapy interruption was found to be a risk factor significantly influencing recurrence in univariate and multivariate analyses. The 5-year overall survival rate in salvage total laryngectomy was 77% and that in salvage conservation laryngectomy was 75%. Conclusion：When a curative radiotherapy was interrupted in early glottic cancer before total dosage irradiation, the possibility of recurrence must be considered. In such cases, by choosing an adequate patient group combined with a proper surgical technique, optimal treatment results can be obtained by salvage conser-vation laryngectomy. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:261-5)

#Laryngeal neoplasms·Radiotherapy·Recurrence·Salvage therapy·Laryngectomy.

참고문헌 (17)

참고문헌 신청

Chatani M / 1997 / Radiation therapy for early glottic carcinoma (T1N0M0): The adverse effect of treatment interruption / Strahlenther Onkol 173 (10) : 502 ~ 506

Cragle SP / 1993 / Laser cordectomy or radiotherapy: Cure rates, communication, and cost / Otolaryngol Head Neck Surg 108 (6) : 648 ~ 654

Groome PA / 2006 / Compromised local control due to treatment interruptions and late treatment breaks in early glottic cancer: Populationbased outcomes study supporting need

Kanonier G / 1996 / Radiotherapy in early glottic carcinoma / Ann Otol Rhinol Laryngol 105 (10) : 759 ~ 763

Kim KH / 1988 / Treatment result of laryngeal cancer / Korean J Otolaryngol-Head Neck Surg 31 (5) : 783 ~ 791

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