알레르기 소아의 아데노이드에서 IgE 항체와 항체조절인자

은영규; 여승근; 정훈; 정대한; 김명구; 변재용; 박문서; 차창일

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자료유형: 학술저널

저자정보: 은영규 여승근 정훈 정대한 김명구 변재용 박문서 차창일

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제7호

발행연도: 2009.1

수록면: 594 - 598 (5page)

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Background and Objectives Immunoglobulin E (IgE) production in adenoid has been debated and the role of adenoid in development of allergy remains largely unknown. To examine the production of local IgE in adenoid involved with IgE-mediated sensitization, we evaluated IgE production and the expression of the transcription factor B cell leukemia/lymphoma-6 (BCL-6) and B lymphocyte inducer of maturation program 1 (Blimp-1) in adenoids. Subjects and Method Ten children with allergic rhinitis (AR) and ten children without any history of AR were enrolled. Immunohistochemical studies of adenoid for IgE, BCL-6 and Blimp-1 were performed. Results IgE was stained mainly in the germinal center and submucosal area and the staining scores of antibody to IgE did not differ signigicantly between children with AR and control. BCL- 6 was mainly stained in mucosa and germinal center and Blimp-1 in mucosa. The scores of antibody to BCL-6 and Blimp-1 in children with AR and control did not show significant differences. Conclusion We found that allergic rhinitis was not involved in the production of IgE nor the expression of the transcription factor BCL-6 and Blimp-1 in adenoid.

#Adenoid·IgE·BCL-6·Blimp-1·Allergy

참고문헌 (19)

참고문헌 신청

Arita M / 2003 / Single cell analysis of adenoid CD5+ B cells and their protective contributions to nasopharyngeal immunity / Laryngoscope 113 (3) : 484 ~ 491

Bernstein JM / 1998 / Th1/Th2 cytokine profiles in the nasopharyngeal lymphoid tissues of children with recurrent otitis media / Ann Otol Rhinol Laryngol 107 (1) : 22 ~ 27

Brandtzaeg P / 1995 / Immunocompetent cells of the upper airway: functions in normal and diseased mucosa / Eur Arch Otorhinolaryngol 252 (1) : 8 ~ 21

Brandtzaeg P / 2003 / Immunology of tonsils and adenoids: everything the ENT surgeon needs to know / Int J Pediatr Otorhinolaryngol 67 (1) : 69 ~ 76

Dent AL / 1997 / Control of inflammation, cytokine expression, and germinal center formation by BCL-6 / Science 276 (5312) : 589 ~ 592

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소속기관 경희대학교 의과대학 이비인후과학교실

주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 이비인후과학

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