지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제6권 제2호
- 발행연도
- 2013.1
- 수록면
- 68 - 72 (5page)
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Objectives. Obstructive sleep apnea syndrome (OSAS) is associated with repeated hypoxia and re-oxygenation. This characteristic of OSAS may cause oxidative stress and DNA damage. However, the link of OSAS with oxidative stress and DNA damage is still controversial. In the current study, we investigated whether OSAS causes DNA damage using alkaline single-cell gel electrophoresis (comet assay) and measuring oxidative stress by monitoring serum malondialdehyde (MDA) levels.
Methods. From March 2009 to August 2010, 51 patients who underwent polysomnography (PSG) during the night were enrolled in this study. We obtained serum from the patients at 6 AM. DNA damage and oxidative stress were evaluated using a comet assay and measuring serum MDA, respectively. We divided the patients into two groups according to the existence of comets appearing in the comet assay. Group 1 included 44 patients with negative assay results and group 2 consisted of seven patients with positive comet assay findings. We compared the age, gender proportion, PSG data (respiratory disturbance index [RDI], lowest O2 saturation level, and arousal index [AI]), time of disease onset, smoking habits, and serum MDA levels between the two groups.
Results. The average age and gender proportion of the two groups were not statistically different (P>0.05). The average of RDI for group 1 was 30.4±18.4 and 8.0±7.7 (P<0.01) for group 2. The average of lowest O2 saturation level for group 1 was 81.2±7.2 and 87.4±6.5 (P<0.05) for group 2. The average AI for group 1 was 32.8±15.1 and 20.8±7.7 (P<0.05) for group 2. Similarly, serum MDA levels of the two groups were not statistically different (P>0.05). No relationship between positive comet assay results and OSAS severity was identified.
Conclusion. Results of the current study showed that OSAS was not associated with DNA damage as measured by comet assays or oxidative stress according to serum MDA levels.
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참고문헌 (18)
참고문헌 신청
Ames BN / 1993 / Oxidants, antioxidants, and the degenerative diseases of aging / Proc Natl Acad Sci U S A 90 (17) : 7915 ~ 7922
Barcelo A / 2000 / Abnormal lipid peroxidation in patients with sleep apnoea / Eur Respir J 16 (4) : 644 ~ 647
Carpagnano GE / 2003 / 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is redu
Christou K / 2003 / Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients / Sleep Breath 7 (3) : 105 ~ 110
Dyugovskaya L / 2002 / Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients / Am J Respir Crit Care Med 165
Barcelo A / 2000 / Abnormal lipid peroxidation in patients with sleep apnoea / Eur Respir J 16 (4) : 644 ~ 647
Carpagnano GE / 2003 / 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is redu
Christou K / 2003 / Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients / Sleep Breath 7 (3) : 105 ~ 110
Dyugovskaya L / 2002 / Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients / Am J Respir Crit Care Med 165
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