삼출성 중이염에서 표면활성단백 A 유전자 대립형질의 분포

한경열; 오천환; 장혁순; 김장묵; 김성운; 오명호

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자료유형: 학술저널

저자정보: 한경열 오천환 장혁순 김장묵 김성운 오명호

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제12호

발행연도: 2006.1

수록면: 1,145 - 1,150 (6page)

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Background and Objectives：Surfactant protein A (SP-A) which plays a role in the innate host defense of lung is also expressedin Eustachian tube. However the genes underlying the susceptibility to otitis media with effusion (OME) are known insufficiently.The current study attempts to evaluate the difference in the allele distribution of SP-A1 and SP-A2 between normal subjects andsubjects with otitis media with effusion. Subjects and Method：PCR-cRFLP-based methodology was used to detect SP-A genotypesin the 38 children with OME, and in the 55 normal newborns for control. Results：The frequencies of specific genotypessuch as 6A2, 1A2 were increased in OME group, but the frequency of 6A3 was increased in control group. Conclusion：It is presumedthat SP-A alleles may be inductive (6A2, 1A2) or protective (6A3) factors for OME. Specific genoytypes of SP-A may be animportant determinant for the predisposition to OME. (Korean J Otolaryngol 2006;49:1145-50)

#삼출성 중이염·표면활성단백 A·PCR-cRFLP. #Otitis media with effusion·Surfactant protein A·PCR-cRFLP.

참고문헌 (16)

참고문헌 신청

/ 1985 / Isolation and characterization of the human pulmonary surfactantapoprotein gene 317 : 361 ~ 3

/ 1987 / The 35 kd pulmonarysurfactant-associated protein is encoded on chromosome 10 76 : 58 ~ 62

/ 1991 / Structural comparisonof recombinant pulmonary surfactant protein SP-A derived from twohuman coding sequences:Implications for the chain composition ofnatural human S

/ 1994 / The effect of surfactant on Eustachian tubefunction in a girbil model of otitis media with effusion 110 : 110 ~ 4

/ 1996 / Human SP-A locus:Allele frequencies and linkage disequilibriumbetween the two surfactant protein A genes 15 : 489 ~ 498

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