비강 및 부비동에 발생하는 점막형 악성 흑색종의임상 양상 및 치료 결과

홍성룡; 김시환; 원태빈; 심우섭; 김용민; 김정훈; 이철희; 민양기; 이재서

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자료유형: 학술저널

저자정보: 홍성룡 김시환 원태빈 심우섭 김용민 김정훈 이철희 민양기 이재서

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제12호

발행연도: 2006.1

수록면: 1,176 - 1,180 (5page)

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Background and Objectives：Mucosal malignant melanoma of the nasal cavity and paranasal sinuses is an uncommon tumorwith poorer prognosis compared with its cutaneous counterpart. The purpose of this study is to investigate the clinical features andtreatment outcomes of mucosal malignant melanoma of the nasal cavity and paranasal sinuses. Subjects and Method：Eighteenpatients who were diagnosed and treated as mucosal malignant melanoma of nasal cavity and paranasal sinuses from 1995 to 2004were included. Male to female ratio was 10 to 8. Their ages ranged from 43 to 87 years with median of 62 years. The medicalrecords were reviewed retrospectively with respect to presenting symptoms, stage, treatment modalities and outcome. Result：The most common symptoms were epistaxis and nasal obstruction. The mean duration of symptom was 4.2 months. Commonlyinvolved sites were middle turbinate, inferior turbinate, maxillary sinus and ethmoid sinus. Eight cases belonged to stage I, ninecases to stage II and only one case to stage III. Among them, seventeen patients underwent surgery with or without radiotherapyand immunotherapy. Of the seventeen patients who underwent surgery, twelve had recurrence and the mean period for recurrencewas 8.2 months. During the follow-up periods, five had distant metastases. Five-year survival rate was 27.2% and the survivalrates according to age, sex, tumor size and stage were not statistically significant. Conclusion：Mucosal malignant melanomas ofthe nasal cavity and paranasal sinuses developed commonly in the 6th to 8th decades. Epistaxis and nasal obstruction were the mostcommon presenting symptoms. Almost all cases belonged to the stage I or II and the mainstay of the treatment was surgery.However, it was associated with frequent recurrences and a poor prognosis. (Korean J Otolaryngol 2006;49:1176-80)

#악성 흑색종·비강·부비동. #Malignant melanoma·Nasal cavity·Paranasal sinuses.

참고문헌 (19)

참고문헌 신청

/ / Malignant melanoma of the nasal cavity and paranasalsinuses : 285 ~ 90

/ / Malignantmelanoma of the nasal cavity and paranasal sinuses : 322 ~ 5

/ / Melanoma of the mucous membrane of the headand neck : 315 ~ 9

/ / Mucosal malignant melanoma of thehead and neck : 22 ~ 7

/ / Mucosal melanoma of the head andneck : 1096 ~ 9

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