메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제6호
발행연도
2007.1
수록면
501 - 507 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background and Objectives:Etiology and pathogenesis of nasal polyps are still not fully understood. Transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10)This study was aimed to evaluate the effect of systemic steroid, which is the most potent medications used for the treatment of nasal polyposis, on the expression of TGF-β and IL-10 in nasal polyps. Subjects and Method:According to the status of steroid treatment, the polyps (n= 22) removed during an endoscopic sinus surgery were divided into treatment or control groups. For treatment group, 30 mg of prednisolone per day was administered preoperatively for seven days. Eosinophil infiltration, expression and concentration of TGF-β1 and IL-10 in nasal polyps were analyzed. Results:Although there was no statistical significance, the infiltration of eosinophils decreased in the treatment group. In the imunohistochemical study, the expression of TGF-β1 decreased in the epithelial layer of the treatment group compared with that of the control group (p= 0.043). Expresion of IL-10 increased in the stromal layer of the treatment group compared with that of the control group (p= 0.008). TGF-β1 concentration measured by ELISA showed no diferences betwen each group. IL-10 concentration increased in the treatment group (p= 0.021). Conclusion:These findings suggest that systemic steroid may exert a beneficial efect on nasal polyp treatment by at least following two mechanisms:the suppression of epithelial diferentiation and proliferation, and squamous metaplasia through the down regulation of TGF-βIL-10. (Korean J Otolaryngol 2007 ;50 :501-7)

목차

등록된 정보가 없습니다.

참고문헌 (19)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0