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논문 기본 정보

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학술저널
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대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제18권 제1호
발행연도
2014.1
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7 - 16 (10page)

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Purpose : To evaluate the prevalence and pattern of perfusion defect (PD) on first-pass stress perfusion MR imaging inrelation with the degree of left ventricular hypertrophy (LVH) and late gadolinium-enhancement (LGE) in patients with apicalhypertrophic cardiomyopathy (APH). Materials and Methods: Cardiac MR imaging with first-pass stress perfusion, cine, and LGE sequence was performed in26 patients with APH from January 2008 to December 2012. We analyzed a total of 416 segments for LV wall thicknesson end-diastolic phase of cine images, and evaluated the number of hypertrophied segment and number of consecutivehypertrophied segment (NCH). We assessed the presence or absence of PD and LGE from all patients. If there was PD, wesubdivided the pattern into sporadic (sporadic-PD) or ring (ring-PD). Using univariate logistic method, we obtained theindependent predictor for presence of overall PD and ring-PD. Results: PD on stress perfusion MRI was observed in 20 patients (76.9%), 12 of them (60%) showed ring-PD. Maximal LVwall thickness and number of hypertrophied segment were independent predictors for overall PD (all, p < 0.05). NCH withmore than 3 segments was an additional independent factor for ring-PD. However, LGE was not statistically related withPD in patients with APH. Conclusion: About three quarters of the patients with APH showed PD, most of them represented as ring-PD. LVH degreeor distribution was related with pattern of PD, however, LGE was not related with PD. Therefore, the clinical significanceof PD in the patients with APH seems to be different from those with non-APH, and further comparison study betweenthe two groups should be carried out.
#Hyperterophic cardiomyopathy #Magnetic resonance imaging #Myocardial perfusion

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참고문헌 (30)

참고문헌 신청
Krams R / 1998 / Decreased coronary flow reserve in hypertrophic cardiomyopathy is related to remodeling of the coronary microcirculation / Circulation 97:230~233 google schola von Dohlen TW / 1989 / Significance of positive or negative thallium-201 scintigraphy in hypertrophic cardiomyopathy / Am J Cardiol 64:498~503 google schola Cannon RO 3rd / 1991 / Myocardial metabolic, hemodynamic, and electrocardiographic significance of reversible thallium-201 abnormalities in hypertrophic cardiomyopathy / Circulation 83:1660~1667 google schola Lee KH / 2003 / Myocardial thallium defects in apical hypertrophic cardiomyopathy are associated with a benign prognosis / Int J Cardiovas Imaging 19:381~388 google schola Panting JR / 2002 / Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging / N Engl J Med 346:1948~1953 google schola

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