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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 94 - 101 (8page)
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초록· 키워드
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Acinetobacter species isolates are important opportunistic pathogens and commonly implicated in nosocomial infections. The therapeutic options for treatment of the bacterial infections are limited because the bacteria isolates are usually multidrug resistant (MDR). In the current study, we investigated various carbapenemase genes in 68 Acinetobacter species isolates. Antimicrobial susceptibilities were tested using the disk diffusion method. Screening of carbapenemase genes was performed via multiplex PCR. In addition, PCR and DNA sequencing were used to identify the carbapenemase genes. Repetitive extragenic palindromic-PCR (REP-PCR) was also performed to assess the clonality of isolates. In our study, A. baumannii isolates were highly resistant to all agents tested while all non-A. baumannii isolates were susceptible to all agents tested, with the exception of aztreonam and cefotaxime. All 51 A. baumannii isolates contained the blaOXA-51 gene and 37 (72.5%) isolates also harbored the blaOXA-23 gene. In addition, 39 MDR A. baumannii isolates were identified in our study and 37 isolates contained the blaOXA-23 gene. The 37 MDR strains harboring blaOXA-23 showed type I (n=22) or type II (n=15) banding patterns on their REP-PCR profiles. Our results suggest clonal relation and horizontal spreading of MDR A. baumannii isolates containing the blaOXA-23 gene at the hospital located in Daejeon. Continuous investigation of antimicrobial resistant determinants and monitoring emergence and dissemination of MDR isolates is required to prevent and control infection and colonization of MDR A. baumannii isolates.
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참고문헌 (17)
참고문헌 신청
Dijkshoorn L / 2007 / An increasing threat in hospitals : multidrug-resistant Acinetobacter baumannii / Nat Rev Microbiol 5:939~951
Nemec A / 2015 / Acinetobacter seifertii sp. nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolated from human clinical specimens / Int J Syst Evol Microbiol 65:934~942
La Scola B / 2006 / Sequencing of the rpoB gene and flanking spacers for molecular identification of Acinetobacter species / J Clin Microbiol 44:827~832
Srinivasan VB / 2009 / Genetic relatedness and molecular characterization of multidrug resistant Acinetobacter baumannii isolated in central Ohio, USA / Ann Clin Microbiol Antimicrob 8:21~22
Poirel L / 2006 / Carbapenem resistance in Acinetobacter baumannii : mechanisms and epidemiology / Clin Microbiol Infect 12:826~836
Nemec A / 2015 / Acinetobacter seifertii sp. nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolated from human clinical specimens / Int J Syst Evol Microbiol 65:934~942
La Scola B / 2006 / Sequencing of the rpoB gene and flanking spacers for molecular identification of Acinetobacter species / J Clin Microbiol 44:827~832
Srinivasan VB / 2009 / Genetic relatedness and molecular characterization of multidrug resistant Acinetobacter baumannii isolated in central Ohio, USA / Ann Clin Microbiol Antimicrob 8:21~22
Poirel L / 2006 / Carbapenem resistance in Acinetobacter baumannii : mechanisms and epidemiology / Clin Microbiol Infect 12:826~836
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