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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 170 - 176 (7page)
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This study examined the antioxidative effects of Cornis fructus (CF) extract on cultured C6 glioma cells. For this purpose, cytotoxicity analysis of chromium trioxide (CrO3) was performed and the protective effects of the CF extract on CrO3–induced cytotoxicity was examined after the C6 glioma cells were cultured for 48 hours. The antioxidative effects, such as electron donating activity (EDA) and lactate dehydrogenase (LDH) activity were also analyzed. In this study, CrO3 decreased the cell viability in a dose dependent manner. The XTT50 value was determined to be 33 M after the cells were treated for 48 hours at a concentrations of 20∼40 M CrO3. The catalase (CAT) antioxidant increased significantly the cell viability that had been decreased by CrO3–induced cytotoxicity. Regarding the protective effect of the CF extract, the cell viability of the CF extract was increased significantly compared to that of CrO3 only. In addition, the CF extract showed antioxidative effects, such as EDA and an inhibitory effect on the LDH activity. These findings suggest that the cytotoxicity of CrO3 is correlated with oxidative stress, and the CF extract effectively prevented CrO3–induced cytotoxicity through the antioxidative effects. In conclusion, natural products, such as the CF extract may be a useful therapeutic agent for the prevention or treatment of toxicity induced by heavy metals via oxidative stress.
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참고문헌 (22)
참고문헌 신청
Pattison DI / 2001 / Chromium (VI) reduction by catecholamines results in DNA cleavage in vitro: relevance to chromium genotoxicity / Chem Res Toxicol 14:500~510
Tso TC / 1999 / Effects of mannitol or catalase on the generation of reactive oxygen species leading to DNA damaged by chromium (VI) reduction with ascorbate / Chem Res Toxicol 12:1002~1009
Zhang Q / 2002 / Comparison of the cytotoxicity, cellular uptake, and DNA-protein induced by potassium chromate in lymphoblast cell line derived three different individuals / Biol Trace Elem Res 86:11~22
Leonard S / 2000 / Role of molecular oxygen in the generation of hydroxyl and superoxide anion radicals during enzymatic Cr (VI)-induced carcinogenesis / J Environ Pathol Toxicol Oncol 19:49~60
Bagchi D / 2001 / Chromium (VI)-induced oxidative stress, apoptosis cell death and modulation of p53 tumor suppressor gene / Mol Cell Biochem 222:149~158
Tso TC / 1999 / Effects of mannitol or catalase on the generation of reactive oxygen species leading to DNA damaged by chromium (VI) reduction with ascorbate / Chem Res Toxicol 12:1002~1009
Zhang Q / 2002 / Comparison of the cytotoxicity, cellular uptake, and DNA-protein induced by potassium chromate in lymphoblast cell line derived three different individuals / Biol Trace Elem Res 86:11~22
Leonard S / 2000 / Role of molecular oxygen in the generation of hydroxyl and superoxide anion radicals during enzymatic Cr (VI)-induced carcinogenesis / J Environ Pathol Toxicol Oncol 19:49~60
Bagchi D / 2001 / Chromium (VI)-induced oxidative stress, apoptosis cell death and modulation of p53 tumor suppressor gene / Mol Cell Biochem 222:149~158
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