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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 235 - 244 (10page)
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초록· 키워드
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Enterotoxigenic Escherichia coli (ETEC) strains producing each F4, F5, F6 and F41 fimbriae were lysed by GI24 peptide. The lysate cells were used as ETEC vaccine candidate. This study was carried out to examine whether intramuscular (im) immunization of pregnant sows with the novel vaccine candidate could effectively protect their neonatal piglets against ETEC colibacillosis. All pregnant sows were primed at 11 weeks and were boosted at 14 weeks of pregnancy. Group A sows were im inoculated with PBS. Group B sows were im immunized with 2×109 the mixture. Seral IgG, colostral IgA and IgG titers from group B sows, and seral IgG and IgA levels in group B piglets were significantly higher than those of group A sows and piglets, respectively. After challenge with wild-type ETEC, diarrhea and mortality was not observed in group B piglets. However, diarrhea was observed in 66.7% of group A piglets, and 33.3% mortality was observed. These findings indicate that im immunization of sows with the mixture of the novel vaccine candidate can effectively protect their offspring from ETEC colibacillosis.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Arora A / 2000 / Refolded outer membrane protein A of Escherichia coli forms ion channels with two conductance states in planar lipid bilayers / J Biol Chem 275 : 1594 ~ 1600
Ascon M / 1998 / Oral immunization with a Salmonella Typhimurium vaccine vector expressing recombinant enterotoxigenic Escherichia coli K99 fimbriae elicits elevated antibody
Baek JH / 2010 / Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae) / Toxicon 55 : 711 ~ 718
Bertschinger HU / 1999 / Diseases of Swine / Iowa State University Press : 431 ~ 468
Brumme S / 2007 / Impact of Salmonella Typhimurium DT104 virulence factors invC and sseD on the onset, clinical course, colonization patterns and immune response of porcine s
Ascon M / 1998 / Oral immunization with a Salmonella Typhimurium vaccine vector expressing recombinant enterotoxigenic Escherichia coli K99 fimbriae elicits elevated antibody
Baek JH / 2010 / Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae) / Toxicon 55 : 711 ~ 718
Bertschinger HU / 1999 / Diseases of Swine / Iowa State University Press : 431 ~ 468
Brumme S / 2007 / Impact of Salmonella Typhimurium DT104 virulence factors invC and sseD on the onset, clinical course, colonization patterns and immune response of porcine s
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