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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국동물위생학회(구 한국가축위생학회) 한국가축위생학회지 한국가축위생학회지 제38권 제3호
발행연도
2015.1
수록면
173 - 180 (8page)

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Environmental pesticides used for insect control can be transferred from plants to animals even to live-stock animals through food chain. Human beings also can be exposed to pesticides by consuming pol-luted dairy products, including meats, eggs and other milk products. Therefore, the Ministry of Food and Drug Safety (MFDS) established Standard for Pesticide Residue Limits in dairy products. The QuEChERS (quick, easy, cheap, effective, rugged and safe) methods for detecting residual pesticides are relatively well established for fruits and vegetables, however, the methods for meat have not been appropriately studied yet. In the present work, pyraclofos was used as an organophosphate pesticide to examine its tissue residue in experimental animals by QuEChERS methods. For this, pyraclofos (150 mg/kg body weight) was orally administered to male rats once a day for 2 days. After 6, 12, and 24 hr of the treatment, the tissue residues in liver and femoral muscle of the rats were determined using QuEChERS methods followed by HPLC analyses. In preliminary studies, the recovery rates of spiking samples of pyraclofos demonstrated approximately 109∼110% from the tissues. In previous study, pyr-aclofos tissue residues were observed with significantly high levels in livers and muscles at 6 hr of oral treatment. Then, they were almost completely disappeared after 24 hr of the administration, indicating the orally exposed pyraclofos is rapidly absorbed and distributed to body organs, then quickly excreted from the body with a negligible level of tissue residue. The alterations in blood chemistry as well as the histopathology of heart, lung, liver, spleen and kidney have also been investigated in the ex-perimental animals for assessing acute toxic effects of pyraclofos. The obtained blood chemistry indexes (ALT and AST) showed maximum peak values at 12 hr after the oral administration and decreased to the normal levels at 24 hr of the treatment. Histopathologic observation exhibited acute hepatic damages at 24 hr of the treatment. In conclusion, we suggest that QuEChERS method can be adequately opti-mized for the analysis of pyraclofos residues in animal tissues.
#QuEChERS method #Pyraclofos #Tissue residue #Acute toxicity #HPLC

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참고문헌 (14)

참고문헌 신청
Codex Alimentarius Commission / / Pesticide Residues in Food. Rome: FAO/WHO Food Standard google schola Ecobichon, D.J. / 1991 / Casarett and Doull’s Toxicology; The Basic Science of Posions / Perganmo Press : 580 ~ 592 google schola Edwards R / 1986 / Comparative toxicity of cis-cypermethrin in rainbow trout, frog, mouse, and quail / Toxicol Appl Pharmacol 84 : 512 ~ 522 google schola Fishel, F. M. / 2007 / Pesticide use trends in the US: Global comparison / Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida google schola Kono Y / 1986 / Relation of AChE and AliE inhibition of anti-AChE insecticides, TIA-230, fenitrothion and carbaryl to their residual activity in Sodoptera litura larvae(Lepid google schola

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