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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 267 - 272 (6page)
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‘Tight junctions (TJ)’ have recently been identified in the granular cell layer of the human epidermis, where they contribute to the normal adhesion between keratinocytes and to the physiologic barrier function of the epidermis. Among the TJ proteins in the epidermis, occludin is an important transmembrane protein, which is considered as a major component. The purpose of this study is to investigate whether regional variation exists in the expression of the tight junction protein occludin in normal human epidermis. Indirect immunofluorescence staining for occludin was performed with specimens taken from different areas of normal skin (4 from each of 7 different anatomical sites, including the scalp, face, posterior neck, upper arm, abdomen, lower back, and inner thigh). The degrees of the expression-intensity in each specimen were estimated with the reciprocals of positive end-point titer of occludin in an indirect immunofluorescence study. The highest degree expression-intensity of the TJ protein occludin among the different areas of normal epidermis was observed on the face and abdomen with a titer of 600 (p=0.001). The lowest intensity of expression of occludin was seen in the epidermis from the upper arm. Skin specimens from the scalp, neck, back, and leg demonstrated intermediate degrees of the expression in intensity. The expression of occludin in the skin samples obtained from different locations of the body showed a statistically significant variation. This suggests that there is a certain degree of regional variation in the expression-intensity of TJ protein ‘occludin’ in the human epidermis.
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참고문헌 (26)
참고문헌 신청
Balda MS / 2000 / Transmembrane proteins of tight junctions / Semin Cell DevBiol 11 : 281 ~ 289
Brandner JM / 2002 / Organization and formation of the tight junction system in human epidermis and cultured keratinocytes / Eur J Cell Biol 81 : 253 ~ 263
Brandner JM / 2003 / Expression and localization of tight junction-associated proteins in human hair follicles / Arch Dermatol Res 295 : 211 ~ 221
Conklin BS / 2002 / Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells / J Surg Res 102 : 13 ~ 21
Feldman GJ / 2005 / Occludin: Structure, function and regulation / Adv Drug Deliv Rev 57 : 883 ~ 917
Brandner JM / 2002 / Organization and formation of the tight junction system in human epidermis and cultured keratinocytes / Eur J Cell Biol 81 : 253 ~ 263
Brandner JM / 2003 / Expression and localization of tight junction-associated proteins in human hair follicles / Arch Dermatol Res 295 : 211 ~ 221
Conklin BS / 2002 / Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells / J Surg Res 102 : 13 ~ 21
Feldman GJ / 2005 / Occludin: Structure, function and regulation / Adv Drug Deliv Rev 57 : 883 ~ 917
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