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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 161 - 167 (7page)
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초록· 키워드
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These commensal intestinal bacteria can enhance the immune system and aid in nutrient absorption but can also act as opportunistic pathogens. Among these intestinal bacteria, the anaerobic Bacteroides fragilis are divided into enterotoxigenic B. fragilis (ETBF) which secrete the B. fragilis toxin (BFT) and non-enterotoxigenic B. fragilis (NTBF) which do not secrete BFT. ETBF can cause diarrhea and colitis in both humans and livestock but can also be found in asymptomatic individuals. ETBF is predominantly found in patients with inflammatory diarrheal diseases and traveller’s diarrhea. Several clinical studies have also reported an increased prevalence of ETBF in human patients with inflammatory bowel disease (IBD), colitis and colorectal cancer. In small animal models (C57BL/6 wild-type mice, germ-free mice, multiple intestinal neoplasia (Min) mice, rabbits and Mongolian gerbils), ETBF have been found to initiate and/or aggravate IBD, colitis and colorectal cancer. BFT induces E-cadherin cleavage in intestinal epithelial cells resulting in loss of epithelial cell integrity. Subsequent activation of the -catenin pathway leads to increased cellular proliferation. In addition, ETBF causes acute and chronic colitis in wild-type mice as well as enhances tumorigenesis in Min mice via activation of the Stat3/Th17 pathway. Currently, ETBF can be detected using a BFT toxin bioassay and by PCR. Advances in molecular biological techniques such as real-time PCR have allowed both researchers as well as clinicians to rapidly detect ETBF in clinical samples. The emergence of more sensitive techniques will likely advance molecular insight into the role of ETBF in colitis and cancer.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Avila-Campos MJ / 2007 / Determination of bft gene subtypes in Bacteroides fragilis clinical isolates / J Clin Microbiol 45 : 1336 ~ 1338
Basset C / 2004 / Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease? / Dig Dis Sci 49 : 1425 ~ 1432
Chen LA / 2015 / Fecal detection of enterotoxigenic Bacteroides fragilis / Eur J Clin Microbiol Infect Dis 34 : 1871 ~ 1877
Chung GT / 1999 / Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis / Infect Immun 67 : 4945 ~ 4949
Franco AA / 1997 / Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene / Infect Immun 65 : 1007 ~ 1013
Basset C / 2004 / Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease? / Dig Dis Sci 49 : 1425 ~ 1432
Chen LA / 2015 / Fecal detection of enterotoxigenic Bacteroides fragilis / Eur J Clin Microbiol Infect Dis 34 : 1871 ~ 1877
Chung GT / 1999 / Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis / Infect Immun 67 : 4945 ~ 4949
Franco AA / 1997 / Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene / Infect Immun 65 : 1007 ~ 1013
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