지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 120 - 131 (12page)
이용수
초록· 키워드
오류제보하기
Renal tubular acidosis(RTA) is a metabolic acidosis due to impaired excretion of hydrogen ion, or reabsorption of bicarbonate, or both by the kidney. These renal tubular abnormalities can occur as an inherited disease or can result from other disorders or toxins that affect the renal tubules. Disorders of bicarbonate reclamation by the proximal tubule are classified as proximal RTA, whereas disorders resulting from a primary defect in distal tubular net hydrogen secretion or from a reduced buffer trapping in the tubular lumen are called distal RTA. Hyperkalemic RTA may occur as a result of aldosterone deficiency or tubular insensitivity to its effects. The clinical classification of renal tubular acidosis has been correlated with our current physiological model of how the nephron excretes acid, and this has facilitated genetic studies that have identified mutations in several genes encoding acid and base ion transporters. Growth retardation is a consistent feature of RTA in infants. Identification and correction of acidosis are important in preventing symptoms and guide approved genetic counseling and testing.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Alper SL / 2005 / Molecular physiology of SLC4 anion exchangers / Experimental Physiology 91 : 153 ~ 161
Alper SL / 2009 / Molecular physiology and genetics of Na+-independent SLC4 anion exchangers / Journal of Experimental Biology 212 : 1672 ~ 1683
Baum M / 1998 / The Fanconi syndrome of cystinosis: insights into the pathophysiology / Pediatric Nephrology 12 : 492 ~ 497
Burgess JL / 1972 / Nephrotoxicity of amphotericin B, with emphasis on changes in tubular function / The American Journal of Medicine 53 : 77 ~ 84
Cheidde L / 2003 / A Novel Mutation in the Anion Exchanger 1 Gene Is Associated With Familial Distal Renal Tubular Acidosis and Nephrocalcinosis / Pediatrics 112 : 1361 ~ 13
Alper SL / 2009 / Molecular physiology and genetics of Na+-independent SLC4 anion exchangers / Journal of Experimental Biology 212 : 1672 ~ 1683
Baum M / 1998 / The Fanconi syndrome of cystinosis: insights into the pathophysiology / Pediatric Nephrology 12 : 492 ~ 497
Burgess JL / 1972 / Nephrotoxicity of amphotericin B, with emphasis on changes in tubular function / The American Journal of Medicine 53 : 77 ~ 84
Cheidde L / 2003 / A Novel Mutation in the Anion Exchanger 1 Gene Is Associated With Familial Distal Renal Tubular Acidosis and Nephrocalcinosis / Pediatrics 112 : 1361 ~ 13
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