지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 36 - 44 (9page)
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초록· 키워드
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Background/Aims: While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB.
The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea.
Methods: The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated.
Results: The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation,and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001)and the treatment modality for the initial hemostasis (OR=0.467, P=0.001).
Conclusions: The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis. (Clin Mol Hepatol 2013;19:36-44)
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참고문헌 (24)
참고문헌 신청
Beppu K / 1981 / Prediction of variceal hemorrhage by esophageal endoscopy / Gastrointest Endosc 27 : 213 ~ 218
Bosch J / 2008 / The management of portal hypertension: rational basis, available treatments and future options / J Hepatol 48 (Suppl 1) : S68 ~ S92
Garcia-Tsao G / 2007 / Practice Guidelines Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Ga
Gimson AE / 1991 / Endoscopic sclerotherapy in the management of gastric variceal haemor
Jalan R / 2000 / UK guidelines on the management of variceal haemorrhage in cirrhotic patients. British Society of Gastroenterology / Gut 46 (Suppl 3-4) : III1 ~ III15
Bosch J / 2008 / The management of portal hypertension: rational basis, available treatments and future options / J Hepatol 48 (Suppl 1) : S68 ~ S92
Garcia-Tsao G / 2007 / Practice Guidelines Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Ga
Gimson AE / 1991 / Endoscopic sclerotherapy in the management of gastric variceal haemor
Jalan R / 2000 / UK guidelines on the management of variceal haemorrhage in cirrhotic patients. British Society of Gastroenterology / Gut 46 (Suppl 3-4) : III1 ~ III15
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