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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 300 - 308 (9page)
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Hepatoblastoma usually occurs in children under the age of 2 years, with very few cases reported in adults. We experienced a case of adult hepatoblastoma in a 36-year-old female with chronic hepatitis B . She had experienced sudden onset abdominal pain. Her serum alpha-fetoprotein level was markedly elevated, and abdominal CT showed a 9-cm mass with internal hemorrhage in the right hepatic lobe with hemoperitoneum, so an emergency hepatic central bisectionectomy was performed. The initial histologic examination revealed that the mass mimicked combined hepatocellular carcinoma and cholangiocarcinoma with spindle-cell metaplasia of the cholangiocarcinoma element. Follow-up abdominal CT performed 3 months later showed a 5.5-cm metastatic mass in the left subphrenic area. Laparoscopic splenectomy with mass excision was performed, and hepatoblastoma was confirmed histologically. A histologic re-examination of previously obtained surgical specimens also confirmed the presence of hepatoblastoma. Metastatic hepatoblastoma was found at multiple sites of the abdomen during follow-up, and so chemotherapy with cisplatin, 5-fluorouracil (5-FU), and vincristine was applied, followed by carboplatin and doxorubicin . Despite surgery and postoperative chemotherapy, she died 12 months after symptom onset. (Clin Mol Hepatol 2015;21:300-308)
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Sugawara W / 2007 / Promoter hypermethylation of the RASSF1A gene predicts the poor outcome of patients with hepatoblastoma / Pediatr Blood Cancer 49:240~249
Mukhopadhyay P / 2007 / Adult hepatoblastoma in a female Down’s / J Assoc Physicians India 55:242~243
Brotto M / 2002 / Distinct patterns of p27/KIP 1 gene expression in hepatoblastoma and prognostic implications with correlation before and after chemotherapy / Hum Pathol 33:198~205
Abenoza P / 1987 / Hepatoblastoma : An immunohistochemical and ultrastructural study / Hum Pathol 18 : 1025 ~ 1035
Ahn HJ / 1997 / Mixed hepatoblastoma in an adult--a case report and literature review / J Korean Med Sci 12 : 369 ~ 373
Mukhopadhyay P / 2007 / Adult hepatoblastoma in a female Down’s / J Assoc Physicians India 55:242~243
Brotto M / 2002 / Distinct patterns of p27/KIP 1 gene expression in hepatoblastoma and prognostic implications with correlation before and after chemotherapy / Hum Pathol 33:198~205
Abenoza P / 1987 / Hepatoblastoma : An immunohistochemical and ultrastructural study / Hum Pathol 18 : 1025 ~ 1035
Ahn HJ / 1997 / Mixed hepatoblastoma in an adult--a case report and literature review / J Korean Med Sci 12 : 369 ~ 373
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