지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 43 - 50 (8page)
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Severe alcoholic hepatitis has very high short term mortality and corticosteroids have been the mainstay of treatment for decades. Patients with Lille score >0.45 are considered non-responders to steroids and have poor outcome. Recently Orthotopic Liver Transplantation (OLT) is being increasingly used as rescue treatment for these patients, without waiting for 6 months of abstinence. Liver transplant is the only rescue treatment which can potentially provide long term benefit for patients who are steroid non-responders. However, with scarcity of organs being a concern, all patients of severe alcoholic hepatitis cannot be chosen for transplantation in an arbitrary way. There is a need for development of predictive tools and objective protocols to select patients who can justify the use of precious liver grafts. With a stringent criteria for selection of patients receiving the graft, liver transplantation in severe alcoholic hepatitis can become a viable rescue therapeutic option conferring significant survival advantage of both short- and long-term basis. The optimal criteria for selection will also prevent misuse of the liver donor pool as well as to prevent mortality in salvageable patients. Further research needs to be done to identify subset of patients which are at low risk of recidivism and also cannot be managed with pharmacotherapy alone. We reviewed the current knowledge on role of OLT in patient with acute severe alcoholic hepatitis in the present review.
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등록된 정보가 없습니다.
참고문헌 (67)
참고문헌 신청
Mendez-Sanchez N / 2005 / Alcoholic liver disease. An update / Ann Hepatol 4:32~42
Naveau S / 1997 / Excess weight risk factor for alcoholic liver disease / Hepatol Baltim Md 25:108~111
Lucey MR / 2009 / Alcoholic hepatitis / N Engl J Med 360:2758~2769
Cohen JA / 1979 / The SGOT/SGPT ratio--an indicator of alcoholic liver disease / Dig Dis Sci 24:835~838
Mutimer DJ / 1993 / Managing severe alcoholic hepatitis complicated by renal failure / Q J Med 86:649~656
Naveau S / 1997 / Excess weight risk factor for alcoholic liver disease / Hepatol Baltim Md 25:108~111
Lucey MR / 2009 / Alcoholic hepatitis / N Engl J Med 360:2758~2769
Cohen JA / 1979 / The SGOT/SGPT ratio--an indicator of alcoholic liver disease / Dig Dis Sci 24:835~838
Mutimer DJ / 1993 / Managing severe alcoholic hepatitis complicated by renal failure / Q J Med 86:649~656
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