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자료유형
학술저널
저자정보
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제20권 제1호
발행연도
2014.1
수록면
56 - 60 (5page)

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Background/Aims: The aims of the present study were to determine the outcomes of inactive hepatitis B virus (HBV)surface antigen (HBsAg) carriers over a 10-year study period and to elucidate the HBV serological profile of their familymembers. Methods: We retrospectively analyzed the medical files of inactive HBsAg carriers followed up at the Department ofInfectious Diseases of Kocatepe University Medical Faculty Hospital between March 2001 and January 2011. Results: In total, 438 inactive HBsAg carriers were enrolled in this trial. The follow-up period was 33.7±22.5 months(mean±SD). Anti-hepatitis-B surface antibody seroconversion occurred in 0.7% of cases, while chronic hepatitis Bwas found in 0.5%. The anti-hepatitis-D virus (HDV) status was evaluated in 400 patients and anti-hepatitis C virus(HCV) in 430. It was found that 1% and 0.2% were positive for anti-HDV and anti-HCV, respectively. HBV serologywas investigated in at least 1 family member of 334/438 (76.3%) patients. The HBsAg positivity rate was 34.6% in 625family members of 334 patients. A comparison of the HBsAg positivity rates in terms of HBV DNA levels in index casesrevealed that HBsAg seropositivity rates were higher in family members of HBV DNA-negative patients than in familymembers of HBV DNA-positive cases (P =0.0001). Conclusions: The HBsAg positivity rate was higher in family members of inactive HBsAg carriers than in the generalpopulation; these family members therefore have a higher risk of HBV transmission. Furthermore, despite negativeHBV DNA levels, transmission risk was not reduced in these patients, and horizontal transmission seems to beindependent of the HBV DNA value.

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