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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 308 - 314 (7page)
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Background/Aims: Whether alcohol intake increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection remains controversial. The aim of this study was to determine the effect of alcohol intake on the development of HCC. Methods: Between January 2006 and August 2008, 146 patients with an initial diagnosis of HCC who were hospitalized in 3 major hospitals in the Incheon area were enrolled as cases. Another 146 cirrhotic patients, who matched the cases by age and sex, were enrolled as controls. All cases and controls were HBsAg positive, and had a history of lifetime alcohol intake. Results: The cases and controls were aged 53±8 and 53±9 years (mean±SD), respectively, with each group comprising 118 males and 28 females. The basal laboratory data, distribution of Child-Pugh class, HBeAg positivity (31.5% vs. 37.7%), HBV DNA level (5.74±2.35 vs. 5.98±2.29 log10 copies/mL), and proportion with a lifetime alcohol intake of more than 292 kg (30.8% vs. 34.9%) did not differ between cases and controls. The cumulative alcohol intake and the proportion of heavy drinkers did not differ between the two groups in male patients. Conclusions: Alcohol intake might not increase the risk of HCC in patients with HBV infection.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bagnardi V / 2001 / A meta-analysis of alcohol drinking and cancer risk / Br J Cancer 85 : 1700 ~ 1705
Chen CJ / 2006 / Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level / JAMA 295 : 65 ~ 73
Corrao G / 1998 / Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis / Hepatology 27 : 914 ~ 91
Donato F / 2002 / Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women / Am J Epidemiol 155 : 323 ~ 331
El-Serag HB / 2001 / The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans / Am J Gastroenterol 96 : 2462 ~ 2467
Chen CJ / 2006 / Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level / JAMA 295 : 65 ~ 73
Corrao G / 1998 / Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis / Hepatology 27 : 914 ~ 91
Donato F / 2002 / Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women / Am J Epidemiol 155 : 323 ~ 331
El-Serag HB / 2001 / The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans / Am J Gastroenterol 96 : 2462 ~ 2467
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