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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 71 - 89 (19page)
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Background/Aims: To investigate sequential changes in laboratory markers after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) and the relationship of these changes to the severity of the underlying liver disease.
Methods: This retrospective analysis included 65 patients (44 males, 21 females) who underwent RFA of HCC. Hematologic and biochemical markers were assessed at the pre-RFA period and 1 day, 2–3 days, and 1–2 weeks after RFA. We classified the subjects into two groups: Child-Pugh A (n=41) and Child-Pugh B (n=24). The ablative margin volume (AMV) of each patient was measured. We analyzed the changes in laboratory profiles from the baseline, and investigated whether these laboratory changes were correlated with the AMV and the Child-Pugh classification.
Results: Most of the laboratory values peaked at 2–3 days after RFA. AMV was significantly correlated with changes in WBC count, hemoglobin level, and serum total bilirubin level (Pearson’s correlation coefficient, 0.324–0.453; P<0.05). The alanine aminotransferase (ALT) level varied significantly over time (P=0.023).
Conclusions: Most of the measured laboratory markers changed from baseline, peaking at 2–3 days. The ALT level was the only parameter for which there was a significant difference after RFA between Child-Pugh A and B patients: it increased significantly more in the Child-Pugh A patients. (Clin Mol Hepatol 2015;21:71-79)
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참고문헌 (23)
참고문헌 신청
/ 2012 / EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56 : 908 ~ 943
Buscarini L / 2001 / Percutaneous radiofrequency ablation of small hepatocellular carcinoma : long-term results / Eur Radiol 11 : 914 ~ 921
Chen MS / 2006 / A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma / Ann Surg 243 : 321
Cizginer S / 2011 / Biochemical and hematologic changes after percutaneous radiofrequency ablation of liver tumors : experience in 83 procedures / J Vasc Interv Radiol 22 :
Dodd GD / 2005 / Percutaneous radiofrequency ablation of hepatic tumors : postablation syndrome / AJR Am J Roentgenol 185 : 51 ~ 57
Buscarini L / 2001 / Percutaneous radiofrequency ablation of small hepatocellular carcinoma : long-term results / Eur Radiol 11 : 914 ~ 921
Chen MS / 2006 / A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma / Ann Surg 243 : 321
Cizginer S / 2011 / Biochemical and hematologic changes after percutaneous radiofrequency ablation of liver tumors : experience in 83 procedures / J Vasc Interv Radiol 22 :
Dodd GD / 2005 / Percutaneous radiofrequency ablation of hepatic tumors : postablation syndrome / AJR Am J Roentgenol 185 : 51 ~ 57
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