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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제17권 제3호
발행연도
2011.1
수록면
189 - 198 (10page)

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Background/Aims: This study was conducted to investigate the assessment of treatment efficacy of radiotherapy (RT) and other therapeutic modalities compared with palliative care only for treatment with advanced hepatocellular carcinoma (HCC). Methods: From 2002 to 2010, based on the case of 47 patients with advanced HCC, we have investigated each patients'Child-Pugh's class, ECOG performance, serum level of alpha fetoprotein and other baseline characteristics that is considered to be predictive variables and values for prognosis of HCC. Out of overall patients, the 29 patients who had received RT were selected for one group and the 18 patients who had received only palliative care were classified for the other. The analysis in survival between the two groups was done to investigate the efficacy of RT. Results: Under the analysis in survival, the mean survival time of total patients group was revealed between 30.1 months and 45.9 months in RT group, while it was 4.8 months in palliative care group, respectively. In the univariate analysis for overall patients, there were significant factors which affected survival rate like as follows: ECOG performance, Child-Pugh's class, the tumor size, the type of tumor, alpha fetoprotein,transarterial chemoembolization, and RT. The regressive analysis in multivariate Cox for total patients. No treatment under radiotherapy and high level of Child-Pugh's class grade were independent predictors of worse overall survival rate in patients. In contrast, for the subset analysis of the twenty-nine patients treated with radiotherapy, the higher serum level of alpha fetoprotein was an independent predictors of worse overall survival rate in patients. Conclusions: We found that the survival of patients with advanced HCC was better with radiotherapy than with palliative care. Therefore, radiotherapy could be a good option for in patients with advanced HCC.
#Hepatocellular carcinoma #Radiotherapy #Survival rate #Alpha-fetoprotein #Child-Pugh class

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참고문헌 (24)

참고문헌 신청
/ / National Cancer Information Center (NCIC) google schola Cheng SH / 1999 / A pilot study of three-dimensional conformal radiotherapy in unresectable hepatocellular carcinoma / J Gastroenterol Hepatol 14 : 1025 ~ 1033 google schola Dawson LA / 2005 / Partial volume tolerance of the liver to radiation / Semin Radiat Oncol 15 : 279 ~ 283 google schola Dhir V / 1992 / Combination chemotherapy and radiation for palliation of hepatocellular carcinoma / Am J Clin Oncol 15 : 304 ~ 307 google schola Dusheiko GM / 1992 / Treatment of small hepatocellular carcinomas / Lancet 340 : 285 ~ 288 google schola

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