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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 281 - 285 (5page)
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초록· 키워드
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Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease characterized by hepatocellular inflammation, necrosis, and fibrosis, which can progress to cirrhosis and fulminant hepatic failure. The standard treatment for AIH includes corticosteroids alone or in combination with azathioprine. Although most patients achieve remission using the standard regimen, some patients do not respond due to either drug intolerance or refractory disease; in such cases alternative immunosuppressive agents should be explored. The second-line therapies are cyclophilin inhibitors such as cyclosporine A or tacrolimus, and nowadays mycophenolate mofetil (MMF) is widely used if azathioprine-based therapies are not tolerated. Although these are recommended as an alternative to the first-line regimen, there is insufficient evidence for the efficacy of second-line therapies, with the evidence based mainly on expert opinion. Therefore, we report an AIH patient receiving the standard regimen in whom remission did not occur due to side effects to azathioprine, but was successfully treated with MMF in combination with corticosteroids as an alternative to the standard regimen.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Manns MP / 2015 / Autoimmune hepatitis--Update 2015 / J hepatol 62:S100~S111
Manns MP / 2010 / Diagnosis and management of autoimmune hepatitis / Hepatology 51:2193~2213
AJ C. / 2002 / Hepatology: A Textbook of Liver Disease / Saunders :1163~1194
Alvarez F / 1999 / International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis / J hepatol 31:929~938
Liberal R / 2013 / Autoimmune hepatitis: a comprehensive review / J Autoimmun 41:126~139
Manns MP / 2010 / Diagnosis and management of autoimmune hepatitis / Hepatology 51:2193~2213
AJ C. / 2002 / Hepatology: A Textbook of Liver Disease / Saunders :1163~1194
Alvarez F / 1999 / International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis / J hepatol 31:929~938
Liberal R / 2013 / Autoimmune hepatitis: a comprehensive review / J Autoimmun 41:126~139
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