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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한고혈압학회 Clinical Hypertension Clinical Hypertension 제17권 제2호
발행연도
2011.1
수록면
57 - 64 (8page)

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Background: Lectin-like, oxidized, low-density lipoprotein receptorreceptors (LOX-1) recognizes recognize vascular oxidized low-density lipoprotein (LDL), which may play an important role in the pathogenesis of atherosclerosis. We investigated the expressions expression of LOX-1 and redox-regulating thyoredoxinthioredoxin systems in a hypertension and hypercholesterolemia rat model. Methods: Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rat (WKY) rats were fed with a normal cholesterol diet (NC) and a high cholesterol diet (HC) for 4 weeks. Plasma LDL cholesterol levels and blood pressure were measured at 1 and 4 weeks. Histological changes of atherosclerosis in the vessel was evaluated by hematoxylin and eosin staining and immunocytochemistry. The expressions expression of LOX-1 and thyoredoixnthioredoxin were measured by Western western blot analysis. Results: In the SHR groupsgroup, blood pressure after 4 weeks was significantly higher than initial levels. LDL-cholesterol levels in the SHR-HC group were increased at 4 weeks (15.3 ± 2.6 mg/dL vs. 20.2 ± 2.6 mg/dL, p < 0.01) compared with the SHR-NC group. In oxyblot analysis, the degree of oxidative stress of in the SHR-HC group was significantly higher than in the SHR-NC group (p < 0.05). The expressions expression of LOX-1 and Trx were was significantly increased in the SHR-HC group compared with the SHR-NC group (p < 0.05) on western blot analysis. Focal overexpressions overexpression of LOX-1 were was observed at the intima layer of the thoracic aorta, and was which wereonly observed in the SHR-HC group. Conclusions: The expressions expression of LOX-1 and oxidative stress were was significantly increased in the “hypertension with hypercholesterol” rat model. These findings suggested suggest that LOX-1 and redox systems may play a certain role in development and progression of atherosclerosis.
#Atherosclerosis #Hypertension #Oxidative stress

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참고문헌 (20)

참고문헌 신청
Adluri RS / 2011 / Thioredoxin 1 enhances neovascularization and reduces ventricular remodeling during chronic myocardial infarction: a study using thioredoxin 1 transgenic google schola Chen J / 2008 / Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes / FASEB Journal 22 : 3581 google schola Chinellato A / 1994 / Effect of cholesterol-supplemented diet in heritable hyperlipidemic Yoshida rats: functional and morphological characterization of thoracic aorta / Ath google schola Fujita Y / 2009 / Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects / Clinical Chemistry 55 : 285 ~ 294 google schola Hofnagel O / 2004 / Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells / Arteriosclerosis, Thrombosis, and Vascular Biology 24 : 1789 ~ 1795 google schola

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