지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 53 - 62 (10page)
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초록· 키워드
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The relationship between salt and hypertension is well established, and salt restriction is widely recommended in the management of hypertension. However, people living in northeast Asia have consumed large amount of salt, and the prevalence of hypertension and the incidence of stroke have been high in that area. Mechanisms of salt-induced hypertension may be complex, but volume expansion in the presence of impaired natriuretic capacity of the kidney and action on the central nervous system and neurohormoral pathways seem to be important. Salt is also involved in changes in blood pressure (BP) caused by other factors, such as weight gain, stress, exercise, potassium, catecholamines, angiotensin, and aldosterone. The interaction between sodium and aldosterone appears to play a critical role in the development of organ damage. The depressor effect of salt restriction in hypertensive patients is well demonstrated although the response of BP varies widely among individuals. Salt restriction decreases BP throughout 24 hours, and its effect may be greater during night compared to daytime in salt-sensitive nondippers. Although excess salt consumption can cause cardiovascular diseases through its effect on BP, recent studied have shown that the association of salt consumption and cardiovascular diseases, such as stroke and heart failure, is independent of BP. Salt reduction is important in the prevention of cardiovascular diseases, however, the effect and safety of aggressive salt restriction remain to be clarified. It is difficult to accomplish and maintain the salt reduction. Both population strategy and individualized approach are important to reduce salt consumption.
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참고문헌 (33)
참고문헌 신청
Guyton AC / 1980 / Arterial pressure and hypertension. Circulatory physiology, 3 / Saunders
Kawano Y / 1984 / Neurohormonal characteristics of cardiovascular response due to intraventricular hypertonic NaCl / Am J Physiol 247(3):422~428
Kawano Y / 1991 / Effects of chronic intraventricular sodium on blood pressure and fluid balance / Hypertension 17:28~35
de Wardener HE / 1980 / Dahl’s hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure : its possible role in essential hypertension / Kidney Int 18:1~9
Kawano Y / 1992 / Sodium and noradrenaline in cerebrospinal fluid and blood in salt-sensitive and non-salt-sensitive essential hypertension / Clin Exp Pharmacol Physiol 19:235~241
Kawano Y / 1984 / Neurohormonal characteristics of cardiovascular response due to intraventricular hypertonic NaCl / Am J Physiol 247(3):422~428
Kawano Y / 1991 / Effects of chronic intraventricular sodium on blood pressure and fluid balance / Hypertension 17:28~35
de Wardener HE / 1980 / Dahl’s hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure : its possible role in essential hypertension / Kidney Int 18:1~9
Kawano Y / 1992 / Sodium and noradrenaline in cerebrospinal fluid and blood in salt-sensitive and non-salt-sensitive essential hypertension / Clin Exp Pharmacol Physiol 19:235~241
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