지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 8 (8page)
이용수
초록· 키워드
오류제보하기
Abstract Introduction: Hypertension is associated with microcirculatory disturbance, and erythrocyte deformability is a major determinant of the microcirculation. However, impairment of erythrocyte deformability in hypertensive patients in relation to antihypertensive treatment is unclear. The present study aimed to investigate this impairment in hypertensive patients under treatment using a highly sensitive and quantitative nickel mesh filtration technique.
Methods: Deformability was evaluated by filterability, defined as the flow rate of a hematocrit-adjusted erythrocyte suspension relative to that of saline under a specific filtration pressure in a pressure-flow curve obtained by continuous filtration. Baseline characteristics of hypertensive patients (n = 101) and age-matched normotensive subjects (n = 14) were obtained from medical records, and diabetic patients were excluded.
Results: Erythrocyte deformability in the hypertensive group was significantly (p = 0.010) lower (87.8 ± 2.2 %) than that of the normotensive group (89.4 ± 1.7 %) and inversely proportional (r = −0.303, p = 0.002) to the mean blood pressure (BP) measured on blood sampling for the filtration study. Stepwise multiple regression analysis demonstrated that this impairment was mostly attributable to the mean BP (p = 0.001), whereas current smoking and episodes of stroke or coronary artery disease were not contributors.
Discussion: These findings indicate that erythrocyte deformability is impaired in the hypertensive patients, which depends on the current BP control rather than target organ damage.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Amaiden MR. / 2012 / Involvement of membrane tubulin in erythrocyte deformability and blood pressure / J Hypertens 30 : 1414 ~ 1422
Arai K. / 1990 / Further investigations of red cell deformability with nickel mesh / Biorheology 27 : 47 ~ 65
Ariyoshi K. / 2010 / Impaired erythrocyte filterability of spontaneously hypertensive rats : investigation by nickel mesh filtration technique / Circ J 74 : 129 ~ 136
Dikalov SI. / 2013 / Role of mitochondrial oxidative stress in hypertension / Am J Physiol. 305 : H1417 ~ H1427
Ejima J. / 2000 / Relationship of high-density lipoprotein cholesterol and red blood cell filterability : cross-sectional study of healthy subjects / Clin Hemorheol Microcirc
Arai K. / 1990 / Further investigations of red cell deformability with nickel mesh / Biorheology 27 : 47 ~ 65
Ariyoshi K. / 2010 / Impaired erythrocyte filterability of spontaneously hypertensive rats : investigation by nickel mesh filtration technique / Circ J 74 : 129 ~ 136
Dikalov SI. / 2013 / Role of mitochondrial oxidative stress in hypertension / Am J Physiol. 305 : H1417 ~ H1427
Ejima J. / 2000 / Relationship of high-density lipoprotein cholesterol and red blood cell filterability : cross-sectional study of healthy subjects / Clin Hemorheol Microcirc
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Reconstructed Three-Dimensional Images and Parameters of Individual Erythrocytes Using Optical Diffraction Tomography Microscopy
Annals of Laboratory Medicine
2019 .01
-
The burden and management strategies of hypertensive crisis in adult patients presenting to emergency departments of district and regional hospitals in Sub-Saharan Africa
Clinical Hypertension
2023 .01
-
Comparison of Efficiency between Pre-storage and Post-storage filtration by Leukoreduction Blood Filter
대한의생명과학회지
2017 .06
-
Can Home Blood Pressure Monitoring Help Control Blood Pressure and Increase Drug Compliance of Hypertensive Patients?
Korean Journal of Family Medicine
2019 .01
-
The 2022 focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension
Clinical Hypertension
2023 .01
-
Defining the hemodynamic response of hypertensive and normotensive subjects through serial timed blood pressure readings in the clinic
Clinical Hypertension
2019 .01
-
HIV-positive demonstrate more salt sensitivity and nocturnal non-dipping blood pressure than HIV-negative individuals
Clinical Hypertension
2021 .01
-
Effects of Erythrocyte Membrane Polyunsaturated Fatty Acids in Overweight, Obese, and Morbidly Obese Korean Women
대한암예방학회지
2017 .01
-
Intensive blood pressure lowering: a practical review
Clinical Hypertension
2021 .01
-
Korea Hypertension Fact Sheet 2023: analysis of nationwide population-based data with a particular focus on hypertension in special populations
Clinical Hypertension
2024 .01
-
Obesity and Hypertension in Association with Diastolic Dysfunction Could Reduce Exercise Capacity
Korean Circulation Journal
2016 .01
-
Obesity and Hypertension in Association with Diastolic Dysfunction Could Reduce Exercise Capacity
Korean Circulation Journal
2016 .01
-
Control Rates of Systolic and Diastolic Blood Pressure among Hypertensive Adults in Korea
Korean Circulation Journal
2019 .01
-
2018 Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis and treatment of hypertension
Clinical Hypertension
2019 .01
-
Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
Clinical Hypertension
2015 .01
-
Adverse Effects of Aggressive Blood Pressure Control in Patients with Intracerebral Hemorrhage
Journal of Neurocritical Care
2017 .01
-
Protective Effects of Auraptene against Free Radical-Induced Erythrocytes Damage
Journal of Pharmacopuncture
2022 .12
-
Suboptimal Management Status of Younger Hypertensive Population in Korea
Korean Circulation Journal
2021 .01
-
Risk factors for hypertensive attack during pheochromocytoma resection
Investigative and Clinical Urology
2016 .01
-
Effect of home blood pressure monitoring for blood pressure control in hypertensive patients taking multiple antihypertensive medications including fimasartan (the FORTE study)
Clinical Hypertension
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0