지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 114 - 120 (7page)
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Purpose: Stress has a deteriorating effect on hippocampal function. It also contributes to symptom exacerbation in many disease states, including overactive bladder and interstitial cystitis/bladder pain syndrome. We investigated the effects of various types of stresses (restraint, noise, and cold) on short-term memory and apoptosis in relation with corticotropin-releasing factor (CRF) expression.
Methods: Rats in the restraint stress group were restrained in a transparent Plexiglas cylinder for 60 minutes twice daily. Rats in the noise stress group were exposed to the 120 dB supersonic machine sound for 60 minutes twice daily. Rats in the cold stress group were placed in a cold chamber at 4°C for 60 minutes twice daily. Each stress was applied for 10 days. A step-down avoidance test for short-term memory, immunohistochemistry for caspase-3 expression, and western blot analysis for Bax and Bcl-2 expressions were conducted.
Results: Latency time was decreased and CRF expression in the hippocampal dentate gyrus and hypothalamic paraventricular nucleus were increased in all of the stress groups. The number of caspase-3-positive cells in the hippocampal dentate gyrus was increased and the expressions of Bax and Bcl2 in the hippocampus were decreased in all of the stress groups.
Conclusions: All of the stress groups experienced short-term memory impairment induced by apoptosis in the hippocampus. The present results suggest the possibility that these stresses affecting the impairment of short-term memory may also induce functional lower urinary tract disorders.
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참고문헌 (22)
참고문헌 신청
Bonaz B / 1998 / Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain / Am J Physiol 275 (5 Pt 2) : R1438 ~ R1449
Chen Y / 2004 / Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress / Neuroscience 126 : 533 ~ 540
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 (Pt 1) : 1 ~ 16
Cory S / 2002 / The Bcl2 family: regulators of the cellular life-or-death switch / Nat Rev Cancer 2 : 647 ~ 656
Hwang L / 2013 / Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expre
Chen Y / 2004 / Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress / Neuroscience 126 : 533 ~ 540
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 (Pt 1) : 1 ~ 16
Cory S / 2002 / The Bcl2 family: regulators of the cellular life-or-death switch / Nat Rev Cancer 2 : 647 ~ 656
Hwang L / 2013 / Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expre
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