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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 259 - 269 (11page)
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Purpose: To simultaneously monitor electrical discharges in various bladder regions and the external urethral sphincter (EUS) during voiding contractions, and to assess the functional role of myogenic modulation of the lower urinary tract (LUT) by ionotropic purinergic receptors containing the P2X3 subunit.
Methods: Female Sprague-Dawley rats were anesthetized with urethane, and implanted with a suprapubic catheter for open cystometry. Flexible microelectrodes were placed ventrally in the bladder dome, upper bladder, lower bladder, and bladder base, along with the middle section of the exposed EUS. Intravesical P2X3-containing receptors were blocked with AF-323, a specific P2X3-P2X2/3 receptor antagonist. A digital electrophysiology amplifier was used to record electrical and cystometric signals throughout the LUT.
Results: Electrical activity in the LUT started before effective voiding contractions. Bladder pressure and electrical waveforms showed consistent out-of-phase activity when compared with the recordings made at the EUS. This pattern was also observed during voiding contractions in the presence of AF-353, supporting the hypothesis that during bladder distension, activation of P2X3-containing receptors is required for voiding contractions. Furthermore, the inhibition of P2X3-containing receptors significantly decreased the amplitude of electrical signals in the urinary bladder, but not the base or EUS.
Conclusions: Our results provide novel information about the regulation of the micturition process by P2X3-containing receptors located in the inner layers of the bladder.
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참고문헌 (25)
참고문헌 신청
Andersson KE / 2011 / Rodent models for urodynamic investigation / Neurourol Urodyn 30 : 636 ~ 646
Andersson KE / 2015 / Purinergic signalling in the urinary bladder / Auton Neurosci 191 : 78 ~ 81
Birder L / 2013 / Urothelial signaling / Physiol Rev 93 : 653 ~ 680
Burnstock G / 2014 / Purinergic signalling in the urinary tract in health and disease / Purinergic Signal 10 : 103 ~ 155
Cockayne DA / 2000 / Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice / Nature 407 : 1011 ~ 1015
Andersson KE / 2015 / Purinergic signalling in the urinary bladder / Auton Neurosci 191 : 78 ~ 81
Birder L / 2013 / Urothelial signaling / Physiol Rev 93 : 653 ~ 680
Burnstock G / 2014 / Purinergic signalling in the urinary tract in health and disease / Purinergic Signal 10 : 103 ~ 155
Cockayne DA / 2000 / Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice / Nature 407 : 1011 ~ 1015
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