지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 65 - 73 (9page)
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Purpose: Granulocyte colony stimulating factor (G-CSF) has been known to increase neutrophil production and have anti-inflammatory properties, but the effect of G-CSF on pulmonary system is in controversy. We investigated whether G-CSF treatment could attenuate hyperoxia-induced lung injury, and whether this protective effect is mediated by the down-modulation of inflammatory responses in a neonatal rat model. Materials and Methods: Newborn Sprague-Dawley rats (Orient Co., Seoul, Korea) were subjected to 14 days of hyperoxia (90% oxygen) beginning within 10 h after birth. G-CSF (20 μg/kg) was administered intraperitoneally on the fourth, fifth, and sixth postnatal days. Results: This treatment significantly improved hyperoxia-induced reduction in body weight gain and lung pathology such as increased mean linear intercept, mean alveolar volume, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling positive cells. Hyperoxia-induced activation of nicotinamide adenine dinucleotide phosphate oxidase, which is responsible for superoxide anion production, as evidenced by upregulation and membrane translocation of p67^phox was significantly attenuated after G-CSF treatment, as were inflammatory responses such as increased myeloperoxidase activity and mRNA expression of transforming growth factor-β. However, the attenuation of other proinflammatory cytokines such as tumor necrosis factor-α and interleukin-6 was not significant. Conclusion: In sum, G-CSF treatment significantly attenuated hyperoxia-induced lung injury by down-modulating the inflammatory responses in neonatal rats.
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참고문헌 (27)
참고문헌 신청
/ / Trial of late surfactant for prevention of bronchopulmonary dysgest plasia (TOLSIRF)
/ / Trial of late surfactant to prevent BPD: A pilot study in ventilated preterm neonates receiving inhaled nitric oxide (TOLSURF Pilot)
Adach K / 2002 / Granulocyte colony-stimulating factor exacerbates the acute lung injury and pulmonary fibrosis induced by intratracheal administration of bleomycin in rats
Babior BM / 1999 / NADPH oxidase: an update / Blood 93 : 1464 ~ 1476
Bland RD / 2005 / Neonatal chronic lung disease in the post-surfactant era / Biol Neonate 88 : 181 ~ 191
/ / Trial of late surfactant to prevent BPD: A pilot study in ventilated preterm neonates receiving inhaled nitric oxide (TOLSURF Pilot)
Adach K / 2002 / Granulocyte colony-stimulating factor exacerbates the acute lung injury and pulmonary fibrosis induced by intratracheal administration of bleomycin in rats
Babior BM / 1999 / NADPH oxidase: an update / Blood 93 : 1464 ~ 1476
Bland RD / 2005 / Neonatal chronic lung disease in the post-surfactant era / Biol Neonate 88 : 181 ~ 191
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