지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,354 - 1,358 (5page)
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Purpose: The function of regulatory B lymphocytes is known to be abnormal in inflammatorydiseases. However, a recent study indicates that IL-10+ B cells seem to be expanded in rheumatoid arthritis (RA). Therefore, the state of IL-10+ B cells in the peripheral blood from RA patients and healthy controls were investigated. Materialsand Methods: CD19+ cells in peripheral blood mononuclear cells were purifiedfrom blood samples of RA patients and age and gender-matched healthy controls,and stimulated with CD40 ligand and CpG for 48 hours. Then, intracellular IL-10 in CD19+ cells was analyzed using flow cytometry. Results: There was no significant difference in the proportion of IL-10+ B cells between 10 RA patients and 10 healthy controls (RA, 0.300±0.07 vs. healthy control 0.459±0.07, p=0.114). The proportion of induced IL-10+ B cells to total B cells in RA patients was significantlyhigher than those in controls (RA, 4.44±3.44% vs. healthy control 2.44± 1.64%, p=0.033). However, the proportion of IL-10+ B cells to total B cells correlatednegatively with disease activity in RA patients (r=-0.398, p=0.040). Erythrocytesedimentation rate or C-reactive protein or medication was not associated with the proportion of IL-10+ B cells. Conclusion: The proportion of induced IL-10+ B cell increased in RA patients compared to healthy control, however, negativelycorrelated with disease activity in RA.
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참고문헌 (28)
참고문헌 신청
Ding Q / 2011 / Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice / J Clin Invest 121:3645~3656
MacDonald KP / 1997 / Functional CD40 ligand is expressed by T cells in rheumatoid arthritis / J Clin Invest 100:2404~2414
Liu MF / 2001 / Expression of CD40 and CD40 ligand among cell populations within rheumatoid synovial compartment / Autoimmunity 34:107~113
Yang M / 2010 / Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells / J Immunol 184:3321~3325
Yehudai D / 2012 / B cell-activating factor enhances interleukin-6 and interleukin-10 production by ODN-activated human B cells / Scand J Immunol 76:371~377
MacDonald KP / 1997 / Functional CD40 ligand is expressed by T cells in rheumatoid arthritis / J Clin Invest 100:2404~2414
Liu MF / 2001 / Expression of CD40 and CD40 ligand among cell populations within rheumatoid synovial compartment / Autoimmunity 34:107~113
Yang M / 2010 / Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells / J Immunol 184:3321~3325
Yehudai D / 2012 / B cell-activating factor enhances interleukin-6 and interleukin-10 production by ODN-activated human B cells / Scand J Immunol 76:371~377
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