지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,341 - 1,347 (7page)
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초록· 키워드
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Purpose: The purpose of this study was to compare once-daily tacrolimus with twice-daily tacrolimus in terms of safety, efficacy, and patient satisfaction. Materialsand Methods: This prospective, randomized, open-label, multicenter study was conducted at three institutes. Patients in the investigational group were convertedfrom tacrolimus twice daily to the same dose of extended-release tacrolimusonce daily at 1 month post-transplantation, while patients in the control group were maintained on tacrolimus twice daily. The efficacies, safeties, and patient satisfactionfor the two drugs at 6 months post-transplantation were compared. Results:Sixty patients were enrolled and randomized to the investigational group (28 of 29 patients completed the study) or the control group (26 of 31 patients completedthe study). At 6 months post-transplantation, composite efficacy failure rates including the incidences of biopsy-confirmed acute rejection in the investigationaland control groups were 0% and 10.7%, respectively; patient survival was 100% in each group. No difference in estimated glomerular filtration rate values were observed at 6 months post-transplantation (p=0.97). The safety and satisfactionprofile (immunosuppressant therapy barrier scale) of once-daily tacrolimus was comparable with that of twice-daily tacrolimus (p=0.35). Conclusion: Conversionfrom twice-daily tacrolimus to once-daily tacrolimus one month after transplantation is safe and effective.
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참고문헌 (19)
참고문헌 신청
Alloway R / 2005 / Conversion of stable kidney transplant recipients from a twice daily Prograf-based regimen to a once daily modified release tacrolimus-based regimen / Tran
Alloway R / 2007 / Two years postconversion from a prograf-based regimen to a once-daily tacrolimus extended-release formulation in stable kidney transplant recipients / Tran
Butler JA / 2004 / Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review / Transplantation 77 : 769 ~ 776
Chisholm MA / 2005 / Development and validation of an immunosuppressant therapy adherence barrier instrument / Nephrol Dial Transplant 20 : 181 ~ 188
Crespo M / 2009 / De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels / Transplant Proc 41 : 2115 ~ 2117
Alloway R / 2007 / Two years postconversion from a prograf-based regimen to a once-daily tacrolimus extended-release formulation in stable kidney transplant recipients / Tran
Butler JA / 2004 / Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review / Transplantation 77 : 769 ~ 776
Chisholm MA / 2005 / Development and validation of an immunosuppressant therapy adherence barrier instrument / Nephrol Dial Transplant 20 : 181 ~ 188
Crespo M / 2009 / De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels / Transplant Proc 41 : 2115 ~ 2117
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