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학술저널
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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제57권 제3호
발행연도
2016.1
수록면
721 - 727 (7page)

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Purpose: Alexithymia, defined as a deficit in the ability to recognize and describe one’s own feelings, may be related to the developmentand maintenance of obsessive-compulsive symptoms. The aim of this study was to evaluate the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and alexithymia in patients with obsessive-compulsive disorder (OCD). Materials and Methods: We recruited 244 patients with OCD (169 males, 75 females). Alexithymia was assessed using the 20-item Toronto Alexithymia Scale (TAS-20), and genotyping of the COMT Val158Met polymorphism was evaluated. Results: Patients with the COMT Val/Val genotype had significantly higher total and “difficulty identifying feelings” (DIF) subdimensionscores than those with the Val/Met or Met/Met genotypes. Patients with the COMT Val/Val genotype had significantly higher “difficulty describing feelings” (DDF) subdimension scores than those with the COMT Val/Met genotype. However, there were no differences in the scores for the “externally oriented thinking” (EOT) subdimension among the three genotypes. Conclusion: These results indicate that the high-activity Val allele of the COMT Val158Met polymorphism is associated with increasedalexithymic traits in patients with OCD. The present finding suggests that alexithymia is an endophenotype of OCD that is mediated by the COMT Val158Met polymorphism.

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