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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
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- 1 - 10 (10page)
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The unique antigenic determinants (Idiotype [Id]) of the immunoglobulin expressed on a given B-cell malignancy can serve as a tumor-specific antigen for active immunotherapy. Therapeutic vaccines targeting the tumor-specific idiotype have demonstrated promising results against lymphomas in phase I/II studies and are currently being evaluated in phase III randomized trials. Additional vaccine therapies being developed include those based on DNA, dendritic cells, gene-modified tumor cells. It is hoped that immunotherapeutic agents, used in tandem or in combination, may in the future allow effective treatment of lymphoid malignancies and delay or even replace the need for conventional cytotoxic therapies.
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참고문헌 (27)
참고문헌 신청
/ 1972 / Myeloma proteins as tumor-specific transplantation antigens 69 : 1540 ~ 4
/ 1974 / Protective and cellular immune responses to idiotypic determinants on cells from a spontaneous lymphoma of NZB/NZW F1 mice 140 : 1547 ~ 58
/ 1975 / Antibody to a molecularly-defined antigen confined to a tumour cell surface 254 : 714 ~ 6
/ 1976 / Tumor immunity induced by preimmunization with BALB/c mouse myeloma protein 56 : 735 ~ 40
/ 1977 / Idiotypic determinants on the surface immunoglobulin of neoplastic lymphocytes:a therapeutic target 36 : 2268 ~ 71
/ 1974 / Protective and cellular immune responses to idiotypic determinants on cells from a spontaneous lymphoma of NZB/NZW F1 mice 140 : 1547 ~ 58
/ 1975 / Antibody to a molecularly-defined antigen confined to a tumour cell surface 254 : 714 ~ 6
/ 1976 / Tumor immunity induced by preimmunization with BALB/c mouse myeloma protein 56 : 735 ~ 40
/ 1977 / Idiotypic determinants on the surface immunoglobulin of neoplastic lymphocytes:a therapeutic target 36 : 2268 ~ 71
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