지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 132 - 136 (5page)
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초록· 키워드
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Purpose: To investigate whether allelic polymorphism of haptoglobin (Hp) is associated with premature rupture of membrane (PROM), the Hp phenotypes of pregnant women with PROM were analyzed. Patients and Methods: The Hp phenotypes of 221 pregnant Korean women (187 control and 34 PROM patients) were determined by benzidine/hydrogen peroxide staining, following native polyacrylamide gel electrophoresis of hemoglobin-mixed sera. The Hp allele frequencies were calculated from the data of Hp phenotypes, and overall association with PROM was evaluated using Pearson Chi- Square test. Results: The polymorphic distribution of the patients cohort who underwent a normal delivery (control group) was similar to that of healthy Koreans. In contrast, however, patients with PROM showed significantly higher occurrence of the Hp 1-1 phenotype than control group (23.5% vs 8.0%). Hp 2-2 phenotype was lower in PROM cohort (38.2%) than in the control group (48.7%). The Hp1 allele frequency in PROM group was significantly higher than that in the control group (0.426 vs 0.297, p=0.034) with odds ratio of 1.762 (95% CI: 1.038-2.991). Conclusion: These findings suggest that pregnant Korean women who possess Hp1 allele (expressed as Hp 1-1 phenotype) have higher incidence of PROM than women with Hp2 allele (expressed as Hp 2-2 phenotype). This is the first study that evaluated the significance of Hp polymorphism with respect to the development of PROM.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Asleh R / 2006 / Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo / Circ Res 99 : 1419 ~ 1425
Berkova N / 2001 / Haptoglobin is present in human endometrium and shows elevated levels in the decidua during pregnancy / Mol Hum Reprod 7 : 747 ~ 754
Borna S / 2005 / Vitamins C and E in the latency period in women with preterm premature rupture of membranes / Int J Gynaecol Obstet 90 : 16 ~ 20
Cid MC / 1993 / Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis / J Clin Invest 91 : 977 ~ 985
Costa-Mallen P / 2008 / The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease / Am J Med Gene
Berkova N / 2001 / Haptoglobin is present in human endometrium and shows elevated levels in the decidua during pregnancy / Mol Hum Reprod 7 : 747 ~ 754
Borna S / 2005 / Vitamins C and E in the latency period in women with preterm premature rupture of membranes / Int J Gynaecol Obstet 90 : 16 ~ 20
Cid MC / 1993 / Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis / J Clin Invest 91 : 977 ~ 985
Costa-Mallen P / 2008 / The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease / Am J Med Gene
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