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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 414 - 421 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Fentanyl was reported to inhibit the α1-adrenoceptor agonist-induced contraction. The goal of this in vitro
study was to identify the α1-adrenoceptor subtype primarily involved in the fentanyl-induced attenuation of
phenylephrine-induced contraction in isolated endothelium-denuded rat aorta. Materials and Methods: Aortic rings
were suspended in order to record isometric tension. Concentration-response curves for phenylephrine (10-9 to 10-5
M) were generated in the presence or absence of one of the following drugs: fentanyl (3×10-7, 10-6, 3×10-6 M), 5-
methylurapidil (3×10-8, 10-7, 3×10-7 M), chloroethylclonidine (10-5 M) and BMY 7378 (3×10-9, 10-8, 3×10-8 M).
Phenylephrine concentration-response curves were generated in the presence or absence of fentanyl in rings
pretreated with either 3×10-9 M prazosin, 10-9 M 5-methylurapidil or 3×10-9 M BMY 7378. Results: Fentanyl (10-6,
3×10-6 M) attenuated phenylephrine-induced contraction in the rat aorta. 5-Methylurapidil and BMY 7378
produced a parallel rightward shift in the phenylephrine concentration-response curve. The pA2 values for 5-
methylurapidil and BMY 7378 were estimated to be 7.71 ± 0.15 and 8.99 ± 0.24, respectively. Fentanyl (10-6 M)
attenuated phenylephrine-induced contraction in rings pretreated with 10-9 M 5-methylurapidil, but did not alter the
rings when pretreated with 3×10-9 M BMY 7378. Pretreatment of the rings with chloroethylclonidine showed a
72.9 ± 2.3% reduction in phenylephrine-induced maximal contraction. Conclusion: The results suggest that
fentanyl attenuates phenylephrine-induced contraction by inhibiting the pathway involved in the α1D-adrenoceptormediated
contraction of the rat aorta.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Arevalo-Leon LE / 2003 / Villalobos- Molina R. Evidence for the role of alpha1D- and alpha1A-adrenoceptors in contraction of the rat mesenteric artery / Vascul Pharmacol 40
Arunlakshana O / 1959 / Some quantitative uses of drug antagonist / Br J Pharmacol Chemother 14 : 48 ~ 58
Asbu.n-Bojalil J / 2002 / Does segmental difference in alpha 1-adrenoceptor subtype explain contractile difference in rat abdominal and thoracic aorta? / Vascul Pharmacol 38
Blaise GA / 1990 / Fentanyl is devoid of major effects on coronary vasoreactivity and myocardial metabolism in experimental animals / Anesthesiology 72 : 535 ~ 541
Buckner SA / 1996 / Alpha 1-adrenoceptor-induced contractility in rat aorta is mediated by the alpha 1 D subtype / Eur J Pharmacol 297 : 241 ~ 248
Arunlakshana O / 1959 / Some quantitative uses of drug antagonist / Br J Pharmacol Chemother 14 : 48 ~ 58
Asbu.n-Bojalil J / 2002 / Does segmental difference in alpha 1-adrenoceptor subtype explain contractile difference in rat abdominal and thoracic aorta? / Vascul Pharmacol 38
Blaise GA / 1990 / Fentanyl is devoid of major effects on coronary vasoreactivity and myocardial metabolism in experimental animals / Anesthesiology 72 : 535 ~ 541
Buckner SA / 1996 / Alpha 1-adrenoceptor-induced contractility in rat aorta is mediated by the alpha 1 D subtype / Eur J Pharmacol 297 : 241 ~ 248
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