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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 793 - 798 (6page)
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초록· 키워드
오류제보하기
Combination therapy with interferon alpha (IFN- ) and ribavirin for 24 or 48 weeks according to HCV genotype has improved the overall sustained virological response (SVR) rates to approximately 40%. The aim of this study was to investigate the long-term efficacy of combination therapy with IFN- and ribavirin for chronic hepatitis C in Koreans. One hundred thirty-eight patients with chronic hepatitis C who received this combination therapy between 1995 and 2003 were analyzed retrospectively. All patients were treated with IFN- 3-6 million units three times weekly in combination with 900-1200 mg/day of ribavirin for 24 weeks. The overall SVR rate was 41.3%. Patients were followed up for a median of 41 months (range, 12-105 months) after completion of therapy. In all of the SVR patients (57 patients), SVR was conserved during the follow-up period. None of the patients progressed to decompensated liver disease or hepatocellular carcinoma (HCC). However, 5 of the 81 non-SVR patients (6.2%) progressed to decompensated liver disease or HCC. In conclusion, combination therapy with IFN- and ribavirin shows good long-term efficacy in patients with chronic hepatitis C in Korea, one of the highest endemic areas of hepatitis B virus (HBV) infection.
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참고문헌 (17)
참고문헌 신청
/ 1906-11 / Long-term mortality after transfusion- associated non-A (n-b hepatitis)
/ 1997 / Natural history of liver fibrosis progression in patients with chronic hepatitis C 349 : 825 ~ 832
/ 1998 / Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C 339 : 1485 ~ 1492
/ 1998 / Prevalence of viral hepatitis markers in Korean patients with hepatocellular carcinoma 13 : 306 ~ 610
/ 1998 / Randomised trial of interferon 2b plus ribavirin for 48 weeks or for 24 weeks versus interferon 2b plus placebo for 48 weeks for treatment of chronic infection with
/ 1997 / Natural history of liver fibrosis progression in patients with chronic hepatitis C 349 : 825 ~ 832
/ 1998 / Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C 339 : 1485 ~ 1492
/ 1998 / Prevalence of viral hepatitis markers in Korean patients with hepatocellular carcinoma 13 : 306 ~ 610
/ 1998 / Randomised trial of interferon 2b plus ribavirin for 48 weeks or for 24 weeks versus interferon 2b plus placebo for 48 weeks for treatment of chronic infection with
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