지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 131 - 138 (8page)
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초록· 키워드
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Purpose: Circumferential resection margin (CRM) involvement is a well-known predictor for poor prognosis in rectal cancer. However, the significance is controversial in some studies. Accordingly, this study attempted to examine the prognostic impact of CRM involvement in stage III rectal cancer. Materials and Methods:Between January 1990 and December 2007, a total of 449 patients who underwent curative resection followed by complete adjuvant chemoradiotherapy for stage III rectal cancer located within 12 cm from the anal verge were selected. Patients were divided into a CRM-positive group (n=79, 17.6%) and a CRM-negative group (n=370, 82.4%). Results: With a median follow-up of 56.6 months, recurrent disease was seen in 53.2 and 43.5% of the CRM-positive and CRM-negative group, respectively. CRM involvement was an independent prognostic factor for 5-year systemic recurrence-free survival (HR: 1.5, CI: 1.0-2.2, p=0.017). However,no significant difference was observed for local recurrence rate between the two groups (13.0 and 13.5%, respectively, p=0.677). Conclusion: In this study, local recurrence rate did not differ according to CRM involvement status in stage III rectal cancer patients, although CRM involvement was shown to be an independent poor prognostic factor. Accordingly, validation of the results of this study by further large prospective randomized trials is warranted.
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참고문헌 (20)
참고문헌 신청
Adam IJ / 1994 / Role of circumferential margin involvement in the local recurrence of rectal cancer / Lancet 344 : 707 ~ 711
Baik SH / 2007 / Prognostic significance of circumferential resection margin following total mesorectal excision and adjuvant chemoradiotherapy in patients with rectal cance
Brown G / 2003 / Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison / Radiology 227
Brown G / 2003 / Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging / Br J Surg 90 : 355 ~ 364
Cecil TD / 2004 / Total mesorectal excision results in low local recurrence rates in lymph node-positive rectal cancer / Dis Colon Rectum 47 : 1145 ~ 1149
Baik SH / 2007 / Prognostic significance of circumferential resection margin following total mesorectal excision and adjuvant chemoradiotherapy in patients with rectal cance
Brown G / 2003 / Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison / Radiology 227
Brown G / 2003 / Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging / Br J Surg 90 : 355 ~ 364
Cecil TD / 2004 / Total mesorectal excision results in low local recurrence rates in lymph node-positive rectal cancer / Dis Colon Rectum 47 : 1145 ~ 1149
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