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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 684 - 693 (10page)
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Purpose: Hepatic stellate cells (HSC) are a type of pericyte with varying characteristics according to their location. However, the electrophysiological properties of HSC are not completely understood. Therefore, this study investigated the difference in the voltage-dependent K+ currents in HSC. Materials and Methods: The voltage-dependent K+ currents in rat HSC were evaluated using the whole cell configuration of the patch-clamp technique. Results: Four different types of voltage-dependent K+ currents in HSC were identified based on the outward and inward K+ currents. Type D had the dominant delayed rectifier K+ current, and type A had the dominant transient outward K+ current. Type I had an inwardly rectifying K+ current, whereas the non-type I did not. TEA (5mM) and 4-AP (2mM) suppressed the outward K+ currents differentially in type D and A. Changing the holding potential from -80 to -40mV reduced the amplitude of the transient outward K+ currents in type A. The inwardly rectifying K+ currents either declined markedly or were sustained in type I during the hyperpolarizing step pulses from -120 to -150mV. Conclusion: There are four different configurations of voltage-dependent K+ currents expressed in cultured HSC. These results are expected to provide information that will help determine the properties of the K+ currents in HSC as well as the different type HSC populations.
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참고문헌 (27)
참고문헌 신청
Bataller R / 2001 / In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels 33 : 956 ~ 962
Biagini G / / Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis : 45 ~ 9
Edwards FR / / Inward rectification in rat cerebral arterioles; involvement of potassium ions in autoregulation : 455 ~ 66
Gasull X / 2001 / Human myofibroblastic hepatic stellate cells express Ca2+-activated K+ channels that modulate the effects of endothelin-1 and nitric oxide 35 : 739 ~ 748
Groff P / hepatology1994;19 / desmin-negative Ito cells in normal rat liver : 440 ~ 6
Biagini G / / Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis : 45 ~ 9
Edwards FR / / Inward rectification in rat cerebral arterioles; involvement of potassium ions in autoregulation : 455 ~ 66
Gasull X / 2001 / Human myofibroblastic hepatic stellate cells express Ca2+-activated K+ channels that modulate the effects of endothelin-1 and nitric oxide 35 : 739 ~ 748
Groff P / hepatology1994;19 / desmin-negative Ito cells in normal rat liver : 440 ~ 6
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