지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 122 - 125 (4page)
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초록· 키워드
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Purpose: Sialic acid-binding Ig-like lectin (Siglec) is an immune inhibitory receptor that plays a role in the negative regulation of the activation of immune cells. This study aimed to evaluate the effects of anti-Siglec-F on plasma and urinary histamine levels in ovalbumin (OVA)-challenged urinary bladder in mice.
Methods: Thirty BALB/c mice were used. In group I (control group, n=5), mice were sensitized with OVA and challenged with saline. In group II (OVA challenge group, n=5), OVA was used for intraperitoneal sensitization and intravesical challenge. The challenged mice in group III (control immunoglobulin G [IgG] group, n=5) and those in group IV (anti-Siglec-F group, n=5) were intraperitoneally pretreated with rabbit control IgG or anti-Siglec-F antibody, respectively. In groups V (N-acetylcysteine[NAC] in OVA challenge group, n=5) and VI (control NAC only, n=5), mice were pretreated with NAC.
Results: Urinary histamine concentrations were significantly higher 7 days after intravesical OVA challenge (P<0.01), whereas plasma histamine levels were not. Pretreatment with anti-Siglec-F antibody significantly prevented the increase in urinary histamine release (P<0.05), whereas pretreatment with the IgG antibody control did not. Also, pretreatment of the OVA challenge group with NAC did not affect the histamine concentration in either urine or plasma.
Conclusions: Systemic anti-Siglec-F treatment showed anti-allergic effects at least on local histamine release, particularly in the lower urinary bladder.
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참고문헌 (15)
참고문헌 신청
Ahluwalia A / 1998 / Ovalbumin-induced neurogenic inflammation in the bladder of sensitized rats / Br J Pharmacol 124 : 190 ~ 196
Bergstrand H / 1992 / Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in
Bochner BS / 2009 / Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors / Clin Exp Allergy 39 : 31
Crocker PR / 2007 / Siglecs and their roles in the immune system / Nat Rev Immunol 7 : 255 ~ 266
Kim YH / 2012 / Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis / ALLERGY 67 (2) : 183 ~ 190
Bergstrand H / 1992 / Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in
Bochner BS / 2009 / Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors / Clin Exp Allergy 39 : 31
Crocker PR / 2007 / Siglecs and their roles in the immune system / Nat Rev Immunol 7 : 255 ~ 266
Kim YH / 2012 / Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis / ALLERGY 67 (2) : 183 ~ 190
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