지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 90 - 98 (9page)
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Purpose: To identify the clinical and pathological characteristics of hard nodules resistant to morcellation (HNRM) during holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia (BPH).
Methods: Between July 2008 and October 2011, 246 patients underwent HoLEP for symptomatic BPH. The first 30 patients were excluded from the analysis due to the learning curve of the procedure. The remaining patients were divided into HNRM (n=29) and non-HNRM groups (n=187), and comparative analysis of the clinical parameters of the two groups was performed.
International prostate symptom score analysis and urodynamic studies were performed preoperatively. Histological analysis was performed after hematoxylin and eosin staining and Masson trichrome staining of the HNRM specimens.
Results: Twenty-nine patients (13.4%) had HNRM. The patients in the HNRM group had significantly higher proportions of advanced age (≥65 years, P=0.029), total prostate volume ≥65 mL (P<0.001), transition zone volume ≥35 mL (P<0.001), serum prostate-specific antigen levels ≥10 ng/mL (P=0.007), and functional urethral length ≥70 mm (P=0.009); larger enucleation weight (P<0.001); longer operation (P=0.001), enucleation (P=0.042), and morcellation times (P<0.001); and higher enucleation ratio (P=0.028) and enucleation efficacy (P=0.001). After adjusting for confounding factors, multivariate logistic regression analysis revealed that age ≥65 years and total prostate volume ≥65 mL were independent risk factors for HNRM. Pathological examination did not reveal any malignant cells, with mainly dense fibrous tissue found in the HNRM.
Conclusions: HNRM can make morcellation cumbersome and time-consuming, and older patients with larger prostates have a higher incidence of HNRM. However, the histopathology of HNRM revealed mainly fibrotic tissue.
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참고문헌 (22)
참고문헌 신청
Barry MJ / 1992 / The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association / J Ur
Barry MJ / 1993 / Winfield HN. Relationship of symptoms of prostatism to commonly used physiological and anatomical measures of t
Bauman TM / 2014 / Characterization of fibrillar collagens and extracellular matrix of glandular benign prostatic hyperplasia nodules / PLoS One 9 : e109102 ~
Berger AP / 2006 / Vascular resistance in the prostate evaluated by colour Doppler ultrasonography: is benign prostatic hyperplasia a vascular disease / BJU Int 98 : 587 ~ 5
Dindo D / 2004 / Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey / Ann Surg 240 : 205 ~ 213
Barry MJ / 1993 / Winfield HN. Relationship of symptoms of prostatism to commonly used physiological and anatomical measures of t
Bauman TM / 2014 / Characterization of fibrillar collagens and extracellular matrix of glandular benign prostatic hyperplasia nodules / PLoS One 9 : e109102 ~
Berger AP / 2006 / Vascular resistance in the prostate evaluated by colour Doppler ultrasonography: is benign prostatic hyperplasia a vascular disease / BJU Int 98 : 587 ~ 5
Dindo D / 2004 / Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey / Ann Surg 240 : 205 ~ 213
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