지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 271 - 282 (12page)
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초록· 키워드
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The desired effect of vaccination is to elicit protective immune responses against infection with pathogenic agents. An inactivated influenza vaccine is able to induce the neutralizing antibodies directed primarily against two surface antigens, hemagglutinin and neuraminidase. These two antigens undergo frequent antigenic drift and hence necessitate the annual update of a new vaccine strain. Besides the antigenic drift, the unpredictable emergence of the pandemic influenza strain, as seen in the 2009 pandemic H1N1, underscores the development of a new influenza vaccine that elicits broadly protective immunity against the diverse influenza strains. Cold-adapted live attenuated influenza vaccines (CAIVs) are advocated as a more appropriate strategy for cross-protection than inactivated vaccines and extensive studies have been conducted to address the issues in animal models. Here, we briefly describe experimental and clinical evidence for cross-protection by the CAIVs against antigenically distant strains and discuss possible explanations for cross-protective immune responses afforded by CAIVs. Potential barriers to the achievement of a universal influenza vaccine are also discussed, which will provide useful guidelines for future research on designing an ideal influenza vaccine with broad protection without causing pathogenic effects such as autoimmunity or attrition of protective immunity against homologous infection.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aymard M / 1999 / Surveillance and impact of influenza in Europe. Groupe Regional d’Observation de la Grippe and European In
Bender BS / 1992 / Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza v
Brehm MA / 2002 / T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens / Nat Immunol 3 : 627 ~ 634
Claas EC / 1998 / Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus / Lancet 351 : 472 ~ 477
Cline TD / 2011 / Increased pathogenicity of a reassortant 2009 pandemic H1N1 influenza virus containing an H5N1 hemagglutinin / J Virol 85 : 12262 ~ 12270
Bender BS / 1992 / Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza v
Brehm MA / 2002 / T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens / Nat Immunol 3 : 627 ~ 634
Claas EC / 1998 / Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus / Lancet 351 : 472 ~ 477
Cline TD / 2011 / Increased pathogenicity of a reassortant 2009 pandemic H1N1 influenza virus containing an H5N1 hemagglutinin / J Virol 85 : 12262 ~ 12270
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