지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1,362 - 1,369 (8page)
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Purpose: The dipeptidyl peptidase IV (DPPIV) gene family exhibits multiple functions and is involved in the pathogenesis of various diseases. It has attracted pharmaceutical interest in the areas of metabolic disorders as well as cancer. However,clinicopathologic significance of DPPIV family in colorectal cancer is not fully understood. Materials and Methods: The clinical relevance of DPPIV and DPP10 expression was determined by immunohistochemical staining, and by assessing its clinicopathologic correlation in 383 colorectal cancer patients with known clinical outcomes. Results: DPPIV was not expressed in normal colon mucosa,but it showed luminal expression in 52 of the 383 colorectal cancers (13.5%). DPPIV expression in tumors was associated with right-sided location of the colon (p=0.010) and more advanced tumor stage (p=0.045). DPP10 was expressed in normal colonic mucosa, but its expression varied in primary colorectal cancer tissues. Loss of DPP10 expression was found in 11 colorectal cancers (CRCs) (2.9%), and multivariate analysis showed that loss of DPP10 expression was an independent factor for poor patient prognosis (p=0.008). Conclusion: DPP10 may play a role in disease progression of colorectal cancer and loss of DPP10 expression in primary CRC is significantly associated with poor survival outcomes.
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참고문헌 (31)
참고문헌 신청
Boonacker E / 2003 / Fluorogenic substrate [Ala-Pro]2-cresyl violet but not Ala-Pro-rhodamine 110 is cleaved specifically by DPPIV activity: a study in living Jurkat cells and CD26/DPPIV-transfected Jurkat cells / J Histochem Cytochem 51:959~968
Asada Y / 1993 / Expression of dipeptidyl aminopeptidase IV activity in human lung carcinoma / Histopathology 23:265~270
Wilson MJ / 2000 / Dipeptidylpeptidase IV activities are elevated in prostate cancers and adjacent benign hyperplastic glands / J Androl 21:220~226
Aratake Y / 1991 / Dipeptidyl aminopeptidase IV staining of cytologic preparations to distinguish benign from malignant thyroid diseases / Am J Clin Pathol 96:306~310
ten Kate J / 1986 / Adenosine deaminase complexing protein (ADCP) immunoreactivity in colorectal adenocarcinoma / Int J Cancer 37:479~485
Asada Y / 1993 / Expression of dipeptidyl aminopeptidase IV activity in human lung carcinoma / Histopathology 23:265~270
Wilson MJ / 2000 / Dipeptidylpeptidase IV activities are elevated in prostate cancers and adjacent benign hyperplastic glands / J Androl 21:220~226
Aratake Y / 1991 / Dipeptidyl aminopeptidase IV staining of cytologic preparations to distinguish benign from malignant thyroid diseases / Am J Clin Pathol 96:306~310
ten Kate J / 1986 / Adenosine deaminase complexing protein (ADCP) immunoreactivity in colorectal adenocarcinoma / Int J Cancer 37:479~485
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