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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1,305 - 1,312 (8page)
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Purpose: Although some CDH13 single nucleotide polymorphisms (SNPs) have been shown to be determinants of blood adiponectin levels, the clinical implications of CDH13 variants are not yet completely understood. The purpose of this study was to evaluate the effects of SNPs of CDH13 on metabolic and vascular phenotypes. Materials and Methods: We included 238 hypertensive subjects and 260 age- and sex-matched controls. Seven tagging-SNPs were identified in the CDH13 gene by whole gene sequencing. The association between these SNP variants and the risk of hypertension, metabolic traits, and carotid intima-media thickness (IMT) was examined. Results: Minor allele carriers of rs12444338 had a lower risk of hypertension, but the association turned out just marginal after adjusting confoudners. Blood glucose levels were higher in the minor allele carriers of c.1407C>T (p=0.01), whereas low-density lipoprotein-cholesterol levels were greater in those of rs6565105 (p=0.02). The minor allele of rs1048612 was associated with a higher body mass index (p=0.01). In addition, the mean carotid IMT was significantly associated with rs12444338 (p=0.02) and rs1048612 (p=0.02). Conclusion: These results provide evidence that CDH13 variants are associated with metabolic traits and carotid atherosclerosis in Koreans. This study shows the multifaceted effects of CDH13 variants on cardiometabolic risk.
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참고문헌 (21)
참고문헌 신청
Adeyemo A / 2009 / A genome-wide association study of hypertension and blood pressure in African Americans / PLoS Genet 5 : e1000564 ~
Breitfeld J / 2012 / Genetics of adiponectin / Biochimie 94 : 2157 ~ 2163
Cardoso CR / 2012 / Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients / J Hypertens 30 : 940 ~ 947
Chung CM / 2011 / A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes / Diabetes 60 : 2417 ~ 24
Diez JJ / 2003 / The role of the novel adipocyte-derived hormone adiponectin in human disease / Eur J Endocrinol 148 : 293 ~ 300
Breitfeld J / 2012 / Genetics of adiponectin / Biochimie 94 : 2157 ~ 2163
Cardoso CR / 2012 / Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients / J Hypertens 30 : 940 ~ 947
Chung CM / 2011 / A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes / Diabetes 60 : 2417 ~ 24
Diez JJ / 2003 / The role of the novel adipocyte-derived hormone adiponectin in human disease / Eur J Endocrinol 148 : 293 ~ 300
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