지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1,516 - 1,523 (8page)
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초록· 키워드
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Purpose: To overcome the potential disadvantages of the use of foreign materials and autologous fat or collagen, we introduce here an autologous plasma gel for injection laryngoplasty. The purpose of this study was to present a new injection material, a plasma gel, and to discuss its clinical effectiveness. Materials and Methods: From 2 mL of blood, the platelet poor serum layer was collected and heated at 100°C for 12 min to form a plasma gel. The plasma gel was then injected into a targeted site; the safety and efficacy thereof were evaluated in 30 rats. We also conducted a phase I/II clinical study of plasma gel injection laryngoplasty in 11 unilateral vocal fold paralysis patients. Results: The plasma gel was semi-solid and an easily injectable material. Of note, plasma gel maintains the same consistency for up to 1 year in a sealed bottle. However, exposure to room air causes the plasma gel to disappear within 1 month. In our animal study, the autologous plasma gel remained in situ for 6 months in animals with minimal inflammation. Clinical study showed that vocal cord palsy was well compensated for with the plasma gel in all patients at two months after injection with no significant complications. Jitter, shimmer, maximum, maximum phonation time (MPT) and mean voice handicap index (VHI) also improved significantly after plasma gel injection. However, because the injected plasma gel was gradually absorbed, 6 patients needed another injection, while the gel remained in place in 2 patients. Conclusion: Injection laryngoplasty with autologous plasma gel may be a useful and safe treatment option for temporary vocal cord palsy.
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참고문헌 (25)
참고문헌 신청
Brunnings W / 1911 / Uber eine neue Behandlungsmethode der Rekurrenslahmung / Verhandl Ver Dtsch Laryngol 18 : 93 ~ 151
Cillo JE Jr / 2007 / Evaluation of autologous platelet-poor plasma gel as a hemostatic adjunct after posterior iliac crest bone harvest / J Oral Maxillofac Surg 65 : 1734 ~
Courey MS / 2004 / Injection laryngoplasty / Otolaryngol Clin North Am 37 : 121 ~ 138
Eppley BL / 2006 / Platelet-rich plasma: a review of biology and applications in plastic surgery / Plast Reconstr Surg 118 : 147e ~ 159e
Floryan KM / 2004 / Intraoperative use of autologous platelet-rich and platelet-poor plasma for orthopedic surgery patients / AORN J 80 : 668 ~ 674
Cillo JE Jr / 2007 / Evaluation of autologous platelet-poor plasma gel as a hemostatic adjunct after posterior iliac crest bone harvest / J Oral Maxillofac Surg 65 : 1734 ~
Courey MS / 2004 / Injection laryngoplasty / Otolaryngol Clin North Am 37 : 121 ~ 138
Eppley BL / 2006 / Platelet-rich plasma: a review of biology and applications in plastic surgery / Plast Reconstr Surg 118 : 147e ~ 159e
Floryan KM / 2004 / Intraoperative use of autologous platelet-rich and platelet-poor plasma for orthopedic surgery patients / AORN J 80 : 668 ~ 674
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