지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 262 - 275 (14page)
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초록· 키워드
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Kawasaki disease (KD) is a self-limited systemic inflammatory illness, and coronary artery lesions (CALs) are a major complication determining the prognosis of the disease. Epidemiologic studies in Asian children suggest that the etiologic agent(s) of KD may be associated with environmental changes. Laboratory findings are useful for the diagnosis of incomplete KD, and they can guide the next-step in treatment of initial intravenous immunoglobulin non-responders. CALs seem to develop in the early stages of the disease before a peak in inflammation. Therefore early treatment, before the peak in inflammation, is mandatory to reduce the risk of CAL progression and severity of CALs. The immunopathogenesis of KD is more likely that of acute rheumatic fever than scarlet fever. A hypothetical pathogenesis of KD is proposed under the premise of a “protein homeostasis system”; where innate and adaptive immune cells control pathogenic proteins that are toxic to host cells at a molecular level. After an infection of unknown KD pathogen(s), the pathogenic proteins produced from an unknown focus, spread and bind to endothelial cells of coronary arteries as main target cells. To control the action of pathogenic proteins and/or substances from the injured cells, immune cells are activated. Initially,non-specific T cells and non-specific antibodies are involved in this reaction, while hyperactivated immune cells produce various cytokines, leading to a cytokine imbalance associated with further endothelial cell injury. After the emergence of specific T cells and specific antibodies against the pathogenic proteins, tissue injury ceases and a repair reaction begins with the immune cells.
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참고문헌 (26)
참고문헌 신청
Amano S / 1980 / General pathology of Kawasaki disease. On the morphological alterations corresponding to the clinical manifestations / Acta Pathol Jpn 30 : 681 ~ 694
Brown TJ / 2001 / CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease / J Infect Dis 184 : 940 ~ 943
Burns JC / 2004 / Kawasaki syndrome / Lancet 364 : 533 ~ 544
Choi IH / 1997 / Clonal expansion of CD8+ T cells in Kawasaki disease / J Immunol 159 : 481 ~ 486
Egami K / 2006 / Prediction of resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease / J Pediatr 149 : 237 ~ 240
Brown TJ / 2001 / CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease / J Infect Dis 184 : 940 ~ 943
Burns JC / 2004 / Kawasaki syndrome / Lancet 364 : 533 ~ 544
Choi IH / 1997 / Clonal expansion of CD8+ T cells in Kawasaki disease / J Immunol 159 : 481 ~ 486
Egami K / 2006 / Prediction of resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease / J Pediatr 149 : 237 ~ 240
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