지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 691 - 700 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: Diabetes is the leading cause of end-stage renal failure. The present study was undertaken to characterize the effects of Corni Fructus on diabetic nephropathy in streptozotocin-induced diabetic rats and their mechanisms. Materials and Methods:Streptozotocin-diabetic rats were orally administrated with Corni Fructus at a dose of 100, 200 or 400 mg/kg body mass for 40 days. Results: Corni Fructus-treated diabetic rats showed significant decreases of blood glucose, urinary protein levels and water consumption. Corni Fructus also reduced serum total cholesterol, total triglyceride and low-density lipoprotein cholesterol levels, and showed a tendency of enhancing high-density lipoprotein cholesterol level. Levels of serum albumin and creatinine in diabetic rats were also significantly reduced by Corni Fructus administration at a dose of 200 and 400 mg/kg body mass compared with non-treated diabetic rats. Corni Fructus increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidose (GSH-px) activities in the kidneys of diabetic rats. Furthermore, Corni Fructus treatment enhanced renal peroxisome proliferator-activated receptor-γ (PPARγ) expression in diabetic rats. Conclusion: These results demonstrated that Corni Fructus may have the potential to protect the animals from diabetic nephropathy by amelioration of oxidative stress and stimulation of PPARγ expression.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ajjan RA / 2006 / Cardiovascular disease prevention in patients with type 2 diabetes: the role of oral anti-diabetic agents / Diab Vasc Dis Res 3 : 147 ~ 158
Anita Kochhar / 2005 / Effect of Supplementation of Traditional Medicinal Plants on Blood Glucose in Non-Insulin-Dependent Diabetics: A Pilot Study / Journal of Medicinal Foo
Asami-Miyagishi R / 2004 / Expression and function of PPARgamma in rat placental development / Biochem Biophys Res Commun 315 : 497 ~ 501
Ceriello A / 1997 / Total radical-trapping antioxidant parameter in NIDDM patients / Diabetes Care 20 : 194 ~ 197
Cooper ME / 1988 / Effects of genetic hypertension on diabetic nephropathy in the rat--functional and structural characteristics / J Hypertens 6 : 1009 ~ 1016
Anita Kochhar / 2005 / Effect of Supplementation of Traditional Medicinal Plants on Blood Glucose in Non-Insulin-Dependent Diabetics: A Pilot Study / Journal of Medicinal Foo
Asami-Miyagishi R / 2004 / Expression and function of PPARgamma in rat placental development / Biochem Biophys Res Commun 315 : 497 ~ 501
Ceriello A / 1997 / Total radical-trapping antioxidant parameter in NIDDM patients / Diabetes Care 20 : 194 ~ 197
Cooper ME / 1988 / Effects of genetic hypertension on diabetic nephropathy in the rat--functional and structural characteristics / J Hypertens 6 : 1009 ~ 1016
이 논문의 저자 정보
최근 본 자료
댓글(0)
0