지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 715 - 722 (8page)
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초록· 키워드
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Purpose: The nephrotic syndrome (NS) is characterized by the favorable response to glucocorticoid therapy and the development of NS may be associated with dysfunctional immune systems. In order to investigate the serum immunoglobulin E (IgE) levels and cytokines activity in pediatric NS, the total of 32 steroid responsive NS patients and 5 healthy controls were enrolled in this study. Materials and Methods:All patients were divided into two groups according to the initial serum IgE levels,such as normal and high IgE group, and their clinical characteristics were evaluated.
In addition, serum levels of interleukin (IL)-4, IL-5, IL-10 and transforming growth factor (TGF)-β were compared and correlated with serum albumin, proteinuria by means of disease severity, and cytokines. Results: In the high IgE group, the higher comorbidity of allergic diseases and relapsing rate, the longer duration of steroid therapy before initial remission, and the higher serum IL-4 and IL-5 levels were found. In all patients, initially higher serum levels of IL-4 and IL-5 declined to normal levels after steroid therapy, whereas the serum IL-10 levels showed no significant difference between nephrotic phase (heavy proteinuria) and remission phase (no proteinuria) of NS. The serum TGF-β levels of the nephrotic phase were significantly lower than those of remission phase or control group, and returned to normal control levels after steroid therapy. Conclusion: This study indicates that initial IgE level is associated with steroid responsiveness and disease severity, and cytokine activities may also be related to the pathogenesis of pediatric steroid responsive NS.
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참고문헌 (26)
참고문헌 신청
/ 1978 / Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the International Study
/ 1981 / The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the In
Abdel-Hafez M / 2009 / Idiopathic nephrotic syndrome and atopy: is there a common link? / Am J Kidney Dis 54 : 945 ~ 953
Araya C / 2009 / T regulatory cell function in idiopathic minimal lesion nephrotic syndrome / Pediatr Nephrol 24 : 1691 ~ 1698
Bacharier LB / 2000 / Molecular mechanisms of IgE regulation / J Allergy Clin Immunol 105 (2 Pt 2) : 547 ~ 558
/ 1981 / The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the In
Abdel-Hafez M / 2009 / Idiopathic nephrotic syndrome and atopy: is there a common link? / Am J Kidney Dis 54 : 945 ~ 953
Araya C / 2009 / T regulatory cell function in idiopathic minimal lesion nephrotic syndrome / Pediatr Nephrol 24 : 1691 ~ 1698
Bacharier LB / 2000 / Molecular mechanisms of IgE regulation / J Allergy Clin Immunol 105 (2 Pt 2) : 547 ~ 558
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